Yersinia pseudotuberculosis is resistant to killing by human neutrophils

Thomas R Laws; Martin S Davey; Christopher Green; Ian A M Cooper; Richard W Titball; Roman A Lukaszewski

doi:10.1016/j.micinf.2011.02.004

Yersinia pseudotuberculosis is resistant to killing by human neutrophils

Thomas R Laws, Martin S Davey, Christopher Green, Ian A M Cooper, Richard W Titball, Roman A Lukaszewski

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The interaction between human neutrophils and the Gram negative gastrointestinal pathogen Yersinia pseudotuberculosis was investigated in vitro. Despite the wealth of data describing how Yersinia can affect the function of neutrophils, there are no published studies describing if neutrophil cells can affect the viability of Y. pseudotuberculosis. The wild-type IP32953 strain of Y. pseudotuberculosis was found to be resistant to killing by human neutrophils. Confocal examination and flow-cytometric analysis of this interaction revealed that bacteria were taken up.

Original language	English
Pages (from-to)	607-11
Number of pages	5
Journal	Microbes and Infection
Volume	13
Issue number	6
DOIs	https://doi.org/10.1016/j.micinf.2011.02.004
Publication status	Published - Jun 2011

Keywords

Endocytosis
Flow Cytometry
Humans
Microbial Viability
Microscopy, Confocal
Neutrophils
Yersinia pseudotuberculosis

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10.1016/j.micinf.2011.02.004

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title = "Yersinia pseudotuberculosis is resistant to killing by human neutrophils",

abstract = "The interaction between human neutrophils and the Gram negative gastrointestinal pathogen Yersinia pseudotuberculosis was investigated in vitro. Despite the wealth of data describing how Yersinia can affect the function of neutrophils, there are no published studies describing if neutrophil cells can affect the viability of Y. pseudotuberculosis. The wild-type IP32953 strain of Y. pseudotuberculosis was found to be resistant to killing by human neutrophils. Confocal examination and flow-cytometric analysis of this interaction revealed that bacteria were taken up.",

keywords = "Endocytosis, Flow Cytometry, Humans, Microbial Viability, Microscopy, Confocal, Neutrophils, Yersinia pseudotuberculosis",

author = "Laws, {Thomas R} and Davey, {Martin S} and Christopher Green and Cooper, {Ian A M} and Titball, {Richard W} and Lukaszewski, {Roman A}",

year = "2011",

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doi = "10.1016/j.micinf.2011.02.004",

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T1 - Yersinia pseudotuberculosis is resistant to killing by human neutrophils

AU - Laws, Thomas R

AU - Davey, Martin S

AU - Green, Christopher

AU - Cooper, Ian A M

AU - Titball, Richard W

AU - Lukaszewski, Roman A

PY - 2011/6

Y1 - 2011/6

N2 - The interaction between human neutrophils and the Gram negative gastrointestinal pathogen Yersinia pseudotuberculosis was investigated in vitro. Despite the wealth of data describing how Yersinia can affect the function of neutrophils, there are no published studies describing if neutrophil cells can affect the viability of Y. pseudotuberculosis. The wild-type IP32953 strain of Y. pseudotuberculosis was found to be resistant to killing by human neutrophils. Confocal examination and flow-cytometric analysis of this interaction revealed that bacteria were taken up.

AB - The interaction between human neutrophils and the Gram negative gastrointestinal pathogen Yersinia pseudotuberculosis was investigated in vitro. Despite the wealth of data describing how Yersinia can affect the function of neutrophils, there are no published studies describing if neutrophil cells can affect the viability of Y. pseudotuberculosis. The wild-type IP32953 strain of Y. pseudotuberculosis was found to be resistant to killing by human neutrophils. Confocal examination and flow-cytometric analysis of this interaction revealed that bacteria were taken up.

KW - Endocytosis

KW - Flow Cytometry

KW - Humans

KW - Microbial Viability

KW - Microscopy, Confocal

KW - Neutrophils

KW - Yersinia pseudotuberculosis

U2 - 10.1016/j.micinf.2011.02.004

DO - 10.1016/j.micinf.2011.02.004

M3 - Article

C2 - 21354325

SN - 1286-4579

VL - 13

SP - 607

EP - 611

JO - Microbes and Infection

JF - Microbes and Infection

IS - 6

ER -

Yersinia pseudotuberculosis is resistant to killing by human neutrophils

Abstract

Keywords

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