Abstract
We have sought to identify signals of assimilation of African male lines in Lebanon by exploring the association of sickle cell disease (SCD) in Lebanon with Y-chromosome haplogroups that are informative of the disease origin and its exclusivity to the Muslim community. A total of 732 samples were analyzed, including 33 SCD patients from Lebanon genotyped for 28 binary markers and 19 short tandem repeats on the non-recombinant segment of the Y chromosome. Genetic organization was identified using populations known to have influenced the genetic structure of the Lebanese population, in addition to African populations with high incidence of SCD. Y-chromosome haplogroup R-M343 sub-lineages distinguish between sub-Saharan African and Lebanese Y chromosomes. We detected a limited penetration of SCD into Lebanese R-M343 carriers, restricted to Lebanese Muslims. We suggest that this penetration brought the sickle cell gene along with the African R-M343, probably with the Saharan caravan slave trade.
Original language | English |
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Pages (from-to) | 29-33 |
Number of pages | 5 |
Journal | Journal of Human Genetics |
Volume | 56 |
Issue number | 1 |
Early online date | 28 Oct 2010 |
DOIs | |
Publication status | Published - Jan 2011 |
Keywords
- Lebanon
- population genetics
- sickle cell disease
- Y STRs
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)