When ceramides meet immune senescence, a GIMAP5 connection

Atrayee Gope; Claudio Mauro

doi:10.1038/s41590-023-01736-2

When ceramides meet immune senescence, a GIMAP5 connection

Atrayee Gope
, Claudio Mauro^*

^*Corresponding author for this work

Inflammation and Ageing

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Apart from lifestyle, environment and chance events, genetic factors have a key role in delineating the health and longevity of an individual. Research by Park et al. has now shed light on the role of mammalian GIMAP5, a longevity-assurance (LASS) gene encoding a GTP-binding protein that regulates ceramide synthesis and cellular senescence.

Original language	English
Number of pages	2
Journal	Nature Immunology
DOIs	https://doi.org/10.1038/s41590-023-01736-2
Publication status	E-pub ahead of print - 23 Jan 2024

Bibliographical note

Acknowledgements
C.M. is supported by a British Heart Foundation Senior Basic Science Research Fellowship (FS/ SBSRF/22/31031[CM1]).

Access to Document

10.1038/s41590-023-01736-2Licence: None: All rights reserved

Cite this

@article{d0378f9e77004572a1f7950d4a889bb5,

title = "When ceramides meet immune senescence, a GIMAP5 connection",

abstract = "Apart from lifestyle, environment and chance events, genetic factors have a key role in delineating the health and longevity of an individual. Research by Park et al. has now shed light on the role of mammalian GIMAP5, a longevity-assurance (LASS) gene encoding a GTP-binding protein that regulates ceramide synthesis and cellular senescence.",

author = "Atrayee Gope and Claudio Mauro",

note = "Acknowledgements C.M. is supported by a British Heart Foundation Senior Basic Science Research Fellowship (FS/ SBSRF/22/31031[CM1]).",

year = "2024",

month = jan,

day = "23",

doi = "10.1038/s41590-023-01736-2",

language = "English",

journal = "Nature Immunology",

issn = "1529-2908",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - When ceramides meet immune senescence, a GIMAP5 connection

AU - Gope, Atrayee

AU - Mauro, Claudio

N1 - Acknowledgements C.M. is supported by a British Heart Foundation Senior Basic Science Research Fellowship (FS/ SBSRF/22/31031[CM1]).

PY - 2024/1/23

Y1 - 2024/1/23

N2 - Apart from lifestyle, environment and chance events, genetic factors have a key role in delineating the health and longevity of an individual. Research by Park et al. has now shed light on the role of mammalian GIMAP5, a longevity-assurance (LASS) gene encoding a GTP-binding protein that regulates ceramide synthesis and cellular senescence.

AB - Apart from lifestyle, environment and chance events, genetic factors have a key role in delineating the health and longevity of an individual. Research by Park et al. has now shed light on the role of mammalian GIMAP5, a longevity-assurance (LASS) gene encoding a GTP-binding protein that regulates ceramide synthesis and cellular senescence.

U2 - 10.1038/s41590-023-01736-2

DO - 10.1038/s41590-023-01736-2

M3 - Comment/debate

C2 - 38263464

SN - 1529-2908

JO - Nature Immunology

JF - Nature Immunology

ER -

When ceramides meet immune senescence, a GIMAP5 connection

Abstract

Bibliographical note

Access to Document

Fingerprint

Cite this