Abstract
Background: Cultural, environmental, and diet-related factors were postulated to lead to a high prevalence of vitamin D deficiency in Kabul's socioeconomically deprived children under 5 years of age. We investigated the prevalence of plasma 25-hydroxyvitamin D (25-OHD) deficiency in such a group.
Methods: Children between 6 months and up to 5 years of age were randomly sampled in the Chindawal area of Kabul in January 2005. Plasma samples were frozen to below -20 degrees C and 25(OH)D3 concentrations estimated by high-pressure liquid chromatography.
Results: For all 107 children tested, the median plasma 25(OH)D concentration was 5 ng/mL with a range of 2-24 ng/mL; 73% had concentrations of <8 ng/mL; 13 other samples were not analyzed due to insufficiency of plasma, staff, or technical problems. About 35 others approached either did not give consent or blood could not be obtained.
Conclusions: This study was conducted in a high-risk population at a peak season for vitamin D deficiency. We conclude that this population of children living in Kabul to be at great risk of developing vitamin D deficiency, rickets, and other possible immunological effects of deficiency.
Original language | English |
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Pages (from-to) | 16-20 |
Number of pages | 5 |
Journal | International Journal for Vitamin and Nutrition Research |
Volume | 78 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 2008 |
Keywords
- children less than 5 years
- vitamin D concentrations
- vitamin D deficiency
- Afghanistan