Validation of agent-based models of surface receptor oligomerisation

Joanne Clark*, Steve Watson, Dylan Owen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Receptor dimerisation and higher order oligomerisation regulates signalling by a wide variety of transmembrane receptors. We discuss how agent-based modelling (ABM) combined with advanced microscopy and structural studies can provide new insights into the regulation of clustering, including spatial considerations, revealing novel targets for therapeutic intervention.
Original languageEnglish
Pages (from-to)643-646
Number of pages4
JournalTrends in Pharmacological Sciences
Volume44
Issue number10
Early online date26 Jul 2023
DOIs
Publication statusPublished - 14 Sept 2023

Keywords

  • agent-based modelling
  • super-resolution
  • single-molecule microscopy
  • membrane receptors

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