Validation of agent-based models of surface receptor oligomerisation

Joanne Clark; Steve Watson; Dylan Owen

doi:10.1016/j.tips.2023.07.002

Validation of agent-based models of surface receptor oligomerisation

Joanne Clark^*, Steve Watson, Dylan Owen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Receptor dimerisation and higher order oligomerisation regulates signalling by a wide variety of transmembrane receptors. We discuss how agent-based modelling (ABM) combined with advanced microscopy and structural studies can provide new insights into the regulation of clustering, including spatial considerations, revealing novel targets for therapeutic intervention.

Original language	English
Pages (from-to)	643-646
Number of pages	4
Journal	Trends in Pharmacological Sciences
Volume	44
Issue number	10
Early online date	26 Jul 2023
DOIs	https://doi.org/10.1016/j.tips.2023.07.002
Publication status	Published - 14 Sept 2023

Keywords

agent-based modelling
super-resolution
single-molecule microscopy
membrane receptors

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10.1016/j.tips.2023.07.002Licence: Creative Commons: Attribution (CC BY)

ClarkJC2023ValidationFinal published version, 928 KBLicence: Creative Commons: Attribution (CC BY)

Fibrin at the interface of platelet activation and thrombus stabilisation
Watson, S. (Principal Investigator)
The Wellcome Trust
1/01/18 → 1/10/24
Project: Research
The platelet ITAM receptors, CLEC-2 and GPVI, in development, maintenance and thromboinflammatory processes in the vasculature
Rainger, E. (Co-Investigator), Kirchhof, P. (Co-Investigator), Brill, A. (Co-Investigator) & Watson, S. (Principal Investigator)
British Heart Foundation
1/08/14 → 31/07/19
Project: Research

Cite this

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title = "Validation of agent-based models of surface receptor oligomerisation",

abstract = "Receptor dimerisation and higher order oligomerisation regulates signalling by a wide variety of transmembrane receptors. We discuss how agent-based modelling (ABM) combined with advanced microscopy and structural studies can provide new insights into the regulation of clustering, including spatial considerations, revealing novel targets for therapeutic intervention.",

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AB - Receptor dimerisation and higher order oligomerisation regulates signalling by a wide variety of transmembrane receptors. We discuss how agent-based modelling (ABM) combined with advanced microscopy and structural studies can provide new insights into the regulation of clustering, including spatial considerations, revealing novel targets for therapeutic intervention.

KW - agent-based modelling

KW - super-resolution

KW - single-molecule microscopy

KW - membrane receptors

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DO - 10.1016/j.tips.2023.07.002

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Validation of agent-based models of surface receptor oligomerisation

Abstract

Keywords

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Projects

Fibrin at the interface of platelet activation and thrombus stabilisation

The platelet ITAM receptors, CLEC-2 and GPVI, in development, maintenance and thromboinflammatory processes in the vasculature

Cite this