Using Discrete Multi-Physics for studying the dynamics of emboli in flexible venous valves

M. Ariane; D. Vigolo; A. Brill; F. G.B. Nash; M. Barigou; A. Alexiadis

doi:10.1016/j.compfluid.2018.01.037

Using Discrete Multi-Physics for studying the dynamics of emboli in flexible venous valves

M. Ariane^*, D. Vigolo, A. Brill, F. G.B. Nash, M. Barigou, A. Alexiadis

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

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Abstract

Emboli, which are parts of blood clots, can be stuck in the vasculature of various organs (most frequently, lungs) and cause their malfunction or even death. In this work, using mathematical modelling, different types of emboli-like structures are studied in a double venous valve system. The model is implemented with a fully Lagrangian Discrete Multi-Physics technique and the flow is governed by flexible walls. The study shows the effect of different diameters and lengths of a free embolus in the flow surrounding the valve. The presence of an embolus strongly affects the dynamics of both the fluid and the leaflets in venous valves and the permanence of the embolus in the valve chamber is narrowly linked with its length.

Original language	English
Pages (from-to)	57-63
Number of pages	7
Journal	Computers and Fluids
Volume	166
Early online date	3 Feb 2018
DOIs	https://doi.org/10.1016/j.compfluid.2018.01.037
Publication status	Published - 30 Apr 2018

Keywords

Biological venous valve
Deep venous thrombosis
Discrete Multi-Physics
Emboli
Mass and Spring Model
Smoothed Particle Hydrodynamics

ASJC Scopus subject areas

General Computer Science
General Engineering

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10.1016/j.compfluid.2018.01.037

Ariane_et_al_Using_discrete_multi-physics_Computer_and_Fluids_2018
Checked for eligibility: 21/03/2018 https://doi.org/10.1016/j.compfluid.2018.01.037
Accepted author manuscript, 2.07 MBLicence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

Cite this

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title = "Using Discrete Multi-Physics for studying the dynamics of emboli in flexible venous valves",

abstract = "Emboli, which are parts of blood clots, can be stuck in the vasculature of various organs (most frequently, lungs) and cause their malfunction or even death. In this work, using mathematical modelling, different types of emboli-like structures are studied in a double venous valve system. The model is implemented with a fully Lagrangian Discrete Multi-Physics technique and the flow is governed by flexible walls. The study shows the effect of different diameters and lengths of a free embolus in the flow surrounding the valve. The presence of an embolus strongly affects the dynamics of both the fluid and the leaflets in venous valves and the permanence of the embolus in the valve chamber is narrowly linked with its length.",

keywords = "Biological venous valve, Deep venous thrombosis, Discrete Multi-Physics, Emboli, Mass and Spring Model, Smoothed Particle Hydrodynamics",

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AU - Ariane, M.

AU - Vigolo, D.

AU - Brill, A.

AU - Nash, F. G.B.

AU - Barigou, M.

AU - Alexiadis, A.

PY - 2018/4/30

Y1 - 2018/4/30

N2 - Emboli, which are parts of blood clots, can be stuck in the vasculature of various organs (most frequently, lungs) and cause their malfunction or even death. In this work, using mathematical modelling, different types of emboli-like structures are studied in a double venous valve system. The model is implemented with a fully Lagrangian Discrete Multi-Physics technique and the flow is governed by flexible walls. The study shows the effect of different diameters and lengths of a free embolus in the flow surrounding the valve. The presence of an embolus strongly affects the dynamics of both the fluid and the leaflets in venous valves and the permanence of the embolus in the valve chamber is narrowly linked with its length.

AB - Emboli, which are parts of blood clots, can be stuck in the vasculature of various organs (most frequently, lungs) and cause their malfunction or even death. In this work, using mathematical modelling, different types of emboli-like structures are studied in a double venous valve system. The model is implemented with a fully Lagrangian Discrete Multi-Physics technique and the flow is governed by flexible walls. The study shows the effect of different diameters and lengths of a free embolus in the flow surrounding the valve. The presence of an embolus strongly affects the dynamics of both the fluid and the leaflets in venous valves and the permanence of the embolus in the valve chamber is narrowly linked with its length.

KW - Biological venous valve

KW - Deep venous thrombosis

KW - Discrete Multi-Physics

KW - Emboli

KW - Mass and Spring Model

KW - Smoothed Particle Hydrodynamics

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Using Discrete Multi-Physics for studying the dynamics of emboli in flexible venous valves

Abstract

Keywords

ASJC Scopus subject areas

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