UPF1 P-body localization

Saverio Brogna, Preethi Ramanathan, Jikai Wen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

NMD (nonsense-mediated mRNA decay) is a mechanism that degrades transcripts containing PTCs (premature translation termination codons). NMD is a translation-associated process that is expected to take place throughout the cytoplasm. However, recent studies have indicated that the core NMD factors UPF1 (up-frameshift-1), UPF2 and UPF3 can associate with P-bodies (processing bodies), which are large cytoplasmic granules replete with proteins involved in general mRNA decay and related processes. It has been proposed that UPF1 directs PTC-containing mRNAs to P-bodies and triggers decay. Here, we discuss the link between P-bodies and NMD in view of recent studies that suggest that P-bodies are not required for NMD in Drosophila.
Original languageEnglish
Pages (from-to)698-700
Number of pages3
JournalBiochemical Society Transactions
Volume36
Issue numberPt 4
DOIs
Publication statusPublished - 1 Aug 2008

Keywords

  • mRNA decay
  • translation
  • up-frameshift-1 (UPF1)
  • premature translation termination codon
  • processing body (P-body)
  • nonsense-mediated mRNA decay (NMD)

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