Understanding the mechanism by which Gd(iii) coiled coils achieve magnetic resonance relaxivity: – a study into the water coordination chemistry

S. L. Newton; A. Franke; A. Zahl; G. Molinaro; A. Kenwright; D. J. Smith; I. Ivanovic-Burmazovic; M. M. Britton; A. F. A. Peacock

doi:10.1039/D3DT02909C

Understanding the mechanism by which Gd(iii) coiled coils achieve magnetic resonance relaxivity: – a study into the water coordination chemistry

S. L. Newton, A. Franke, A. Zahl, G. Molinaro, A. Kenwright, D. J. Smith, I. Ivanovic-Burmazovic^*, M. M. Britton^*, A. F. A. Peacock^*

^*Corresponding author for this work

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Abstract

A class of Gd(III) coiled coils achieve high MRI relaxivity, in part due to their slow rotational correlation time. However, extending their length is unable to further enhance performance, as the mechanism by which relaxivity is achieved is dominated by the presence of three inner sphere waters in rapid exchange, through an associative mechanism.

Original language	English
Pages (from-to)	15665-15668
Number of pages	4
Journal	Dalton Transactions
Volume	52
Issue number	43
Early online date	24 Oct 2023
DOIs	https://doi.org/10.1039/D3DT02909C
Publication status	Published - 21 Nov 2023

Bibliographical note

Acknowledgments:
SLN gratefully acknowledges financial support from the EPSRC through a studentship from the PSIBS Doctoral Training Centre (EP/F50053X/1), and sponsorship from the Royal Society of Chemistry NMR Discussion Group. We thank the University of Birmingham and EPSRC grant EP/K039245/1 for support of this research. IIB and AF thank the DFG for supporting a high-pressure NMR facility through the programme Major Research Instrumentation as per Art. 91b GG as well as Ludwig-Maximilians-Universität München and its Faculty of Chemistry and Pharmacy.

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Chemistry at Birmingham: a Response to the EPSRC Call: Core Capability for Chemistry Research
Simpkins, N., Anderson, P., Britton, M., Bunch, J., Preece, J. & Slater, P.
Engineering & Physical Science Research Council
1/01/13 → 31/03/13
Project: Research

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Newton, S. L., Franke, A., Zahl, A., Molinaro, G., Kenwright, A., Smith, D. J., Ivanovic-Burmazovic, I., Britton, M. M., & Peacock, A. F. A. (2023). Understanding the mechanism by which Gd(iii) coiled coils achieve magnetic resonance relaxivity: – a study into the water coordination chemistry. Dalton Transactions, 52(43), 15665-15668. https://doi.org/10.1039/D3DT02909C

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abstract = "A class of Gd(III) coiled coils achieve high MRI relaxivity, in part due to their slow rotational correlation time. However, extending their length is unable to further enhance performance, as the mechanism by which relaxivity is achieved is dominated by the presence of three inner sphere waters in rapid exchange, through an associative mechanism.",

author = "Newton, {S. L.} and A. Franke and A. Zahl and G. Molinaro and A. Kenwright and Smith, {D. J.} and I. Ivanovic-Burmazovic and Britton, {M. M.} and Peacock, {A. F. A.}",

note = "Acknowledgments: SLN gratefully acknowledges financial support from the EPSRC through a studentship from the PSIBS Doctoral Training Centre (EP/F50053X/1), and sponsorship from the Royal Society of Chemistry NMR Discussion Group. We thank the University of Birmingham and EPSRC grant EP/K039245/1 for support of this research. IIB and AF thank the DFG for supporting a high-pressure NMR facility through the programme Major Research Instrumentation as per Art. 91b GG as well as Ludwig-Maximilians-Universit{\"a}t M{\"u}nchen and its Faculty of Chemistry and Pharmacy.",

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AU - Smith, D. J.

AU - Ivanovic-Burmazovic, I.

AU - Britton, M. M.

AU - Peacock, A. F. A.

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AB - A class of Gd(III) coiled coils achieve high MRI relaxivity, in part due to their slow rotational correlation time. However, extending their length is unable to further enhance performance, as the mechanism by which relaxivity is achieved is dominated by the presence of three inner sphere waters in rapid exchange, through an associative mechanism.

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Understanding the mechanism by which Gd(iii) coiled coils achieve magnetic resonance relaxivity: – a study into the water coordination chemistry

Abstract

Bibliographical note

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Chemistry at Birmingham: a Response to the EPSRC Call: Core Capability for Chemistry Research

Cite this