TY - JOUR
T1 - Treatment of lobar atelectasis with bronchoscopically administered recombinant human deoxyribonuclease in cystic fibrosis?
AU - McLaughlin, Aisling
AU - McGrath, Emmet
AU - Barry, R
AU - Egan, JJ
AU - Gallagher, CG
PY - 2008/1/1
Y1 - 2008/1/1
N2 - INTRODUCTION
Recombinant human deoxyribonuclease (rhDNase) reduces sputum viscosity and improves pulmonary function in cystic fibrosis (CF).
OBJECTIVE
The objective of this study was to describe our experience in which rhDNase (Pulmozyme; Roche, Basel, Switzerland) was administered by bronchoscopic instillation into atelectatic lobes in five adults with CF.
CONCLUSION
We found this method successful in treating lobar atelectasis, which was resistant to conventional therapy with antibiotics and physiotherapy. In all but one of the cases we described, administration of DNase in this manner resulted in a radiographic and clinical improvement of the atelectasis. We recommend that respiratory physicians consider this as a second line treatment in the management of atelectasis.
AB - INTRODUCTION
Recombinant human deoxyribonuclease (rhDNase) reduces sputum viscosity and improves pulmonary function in cystic fibrosis (CF).
OBJECTIVE
The objective of this study was to describe our experience in which rhDNase (Pulmozyme; Roche, Basel, Switzerland) was administered by bronchoscopic instillation into atelectatic lobes in five adults with CF.
CONCLUSION
We found this method successful in treating lobar atelectasis, which was resistant to conventional therapy with antibiotics and physiotherapy. In all but one of the cases we described, administration of DNase in this manner resulted in a radiographic and clinical improvement of the atelectasis. We recommend that respiratory physicians consider this as a second line treatment in the management of atelectasis.
U2 - 10.1111/j.1752-699X.2007.00024.x
DO - 10.1111/j.1752-699X.2007.00024.x
M3 - Article
C2 - 20298317
VL - 2
SP - 123
EP - 126
JO - The Clinical Respiratory Journal
JF - The Clinical Respiratory Journal
IS - 2
ER -