Treatment of active Crohn's disease in children using partial enteral nutrition with liquid formula: a randomised controlled trial

T Johnson; SM Hill; Michael Murphy; Anita MacDonald; A Thomas

doi:10.1136/gut.2004.062554

Treatment of active Crohn's disease in children using partial enteral nutrition with liquid formula: a randomised controlled trial

T Johnson, SM Hill, Michael Murphy, Anita MacDonald, A Thomas

Birmingham Medical School

Research output: Contribution to journal › Article

150 Citations (Scopus)

Abstract

BACKGROUND AND AIMS: Total enteral nutrition (TEN) with a liquid formula can suppress gut inflammation and induce remission in active Crohn's disease. The mechanism is obscure. Studies have suggested that long term nutritional supplementation with a liquid formula (partial enteral nutrition (PEN)) may also suppress inflammation and prevent relapse. The aim of this study was to compare PEN with conventional TEN in active Crohn's disease. PATIENTS AND METHODS: Fifty children with a paediatric Crohn's disease activity index (PCDAI)>20 were randomly assigned to receive 50% (PEN) or 100% (TEN) of their energy requirement as elemental formula for six weeks. The PEN group was encouraged to eat an unrestricted diet while those receiving TEN were not allowed to eat. The primary outcome was achievement of remission (PCDAI

Original language	English
Pages (from-to)	356-61
Number of pages	6
Journal	Gut
Volume	55
DOIs	https://doi.org/10.1136/gut.2004.062554
Publication status	Published - 1 Mar 2006

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abstract = "BACKGROUND AND AIMS: Total enteral nutrition (TEN) with a liquid formula can suppress gut inflammation and induce remission in active Crohn's disease. The mechanism is obscure. Studies have suggested that long term nutritional supplementation with a liquid formula (partial enteral nutrition (PEN)) may also suppress inflammation and prevent relapse. The aim of this study was to compare PEN with conventional TEN in active Crohn's disease. PATIENTS AND METHODS: Fifty children with a paediatric Crohn's disease activity index (PCDAI)>20 were randomly assigned to receive 50% (PEN) or 100% (TEN) of their energy requirement as elemental formula for six weeks. The PEN group was encouraged to eat an unrestricted diet while those receiving TEN were not allowed to eat. The primary outcome was achievement of remission (PCDAI",

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AU - Johnson, T

AU - Hill, SM

AU - Murphy, Michael

AU - MacDonald, Anita

AU - Thomas, A

PY - 2006/3/1

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AB - BACKGROUND AND AIMS: Total enteral nutrition (TEN) with a liquid formula can suppress gut inflammation and induce remission in active Crohn's disease. The mechanism is obscure. Studies have suggested that long term nutritional supplementation with a liquid formula (partial enteral nutrition (PEN)) may also suppress inflammation and prevent relapse. The aim of this study was to compare PEN with conventional TEN in active Crohn's disease. PATIENTS AND METHODS: Fifty children with a paediatric Crohn's disease activity index (PCDAI)>20 were randomly assigned to receive 50% (PEN) or 100% (TEN) of their energy requirement as elemental formula for six weeks. The PEN group was encouraged to eat an unrestricted diet while those receiving TEN were not allowed to eat. The primary outcome was achievement of remission (PCDAI

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Treatment of active Crohn's disease in children using partial enteral nutrition with liquid formula: a randomised controlled trial

Abstract

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