Titration of Insulin Glargine in Patients with Type 2 Diabetes Mellitus in Asia: Physician- Versus Patient-Led? Rationale of the Asian Treat to Target Lantus Study (ATLAS)

M Odawara; A Misra; M Shestakova; CY Pan; A Jabbar; Nick Freemantle; K Admane

doi:10.1089/dia.2010.0170

Titration of Insulin Glargine in Patients with Type 2 Diabetes Mellitus in Asia: Physician- Versus Patient-Led? Rationale of the Asian Treat to Target Lantus Study (ATLAS)

M Odawara, A Misra, M Shestakova, CY Pan, A Jabbar, Nick Freemantle, K Admane

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Abstract

Objective: The AT-LANTUS Study demonstrated that a simple subject-administered titration algorithm significantly improved glycemic control with a low incidence of severe hypoglycemia compared with a physician-managed titration. However, in the AT-LANTUS Study Asian patients were under-represented, and more than 70% of the patients were already treated with insulin. The Asian Treat to Target Lantus Study (ATLAS) will compare the effectiveness of a patient-versus physician-led initiation of insulin glargine-based basal management in the specific setting of Asia and Russia (as is routinely used in Western countries). This report presents the study design of ATLAS. Methods: Subjects are 40-75 years old (body mass index >= 20 and >= 40 kg/m(2)) with type 2 diabetes mellitus (T2DM) of >2 years in duration, suboptimally controlled (hemoglobin A1c [HbA1c] >= 7.0% and

Original language	English
Pages (from-to)	67-72
Number of pages	6
Journal	Diabetes Technology & Therapeutics
Volume	13
Issue number	1
DOIs	https://doi.org/10.1089/dia.2010.0170
Publication status	Published - 1 Jan 2011

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10.1089/dia.2010.0170

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abstract = "Objective: The AT-LANTUS Study demonstrated that a simple subject-administered titration algorithm significantly improved glycemic control with a low incidence of severe hypoglycemia compared with a physician-managed titration. However, in the AT-LANTUS Study Asian patients were under-represented, and more than 70% of the patients were already treated with insulin. The Asian Treat to Target Lantus Study (ATLAS) will compare the effectiveness of a patient-versus physician-led initiation of insulin glargine-based basal management in the specific setting of Asia and Russia (as is routinely used in Western countries). This report presents the study design of ATLAS. Methods: Subjects are 40-75 years old (body mass index >= 20 and >= 40 kg/m(2)) with type 2 diabetes mellitus (T2DM) of >2 years in duration, suboptimally controlled (hemoglobin A1c [HbA1c] >= 7.0% and ",

author = "M Odawara and A Misra and M Shestakova and CY Pan and A Jabbar and Nick Freemantle and K Admane",

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doi = "10.1089/dia.2010.0170",

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AU - Odawara, M

AU - Misra, A

AU - Shestakova, M

AU - Pan, CY

AU - Jabbar, A

AU - Freemantle, Nick

AU - Admane, K

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Objective: The AT-LANTUS Study demonstrated that a simple subject-administered titration algorithm significantly improved glycemic control with a low incidence of severe hypoglycemia compared with a physician-managed titration. However, in the AT-LANTUS Study Asian patients were under-represented, and more than 70% of the patients were already treated with insulin. The Asian Treat to Target Lantus Study (ATLAS) will compare the effectiveness of a patient-versus physician-led initiation of insulin glargine-based basal management in the specific setting of Asia and Russia (as is routinely used in Western countries). This report presents the study design of ATLAS. Methods: Subjects are 40-75 years old (body mass index >= 20 and >= 40 kg/m(2)) with type 2 diabetes mellitus (T2DM) of >2 years in duration, suboptimally controlled (hemoglobin A1c [HbA1c] >= 7.0% and

AB - Objective: The AT-LANTUS Study demonstrated that a simple subject-administered titration algorithm significantly improved glycemic control with a low incidence of severe hypoglycemia compared with a physician-managed titration. However, in the AT-LANTUS Study Asian patients were under-represented, and more than 70% of the patients were already treated with insulin. The Asian Treat to Target Lantus Study (ATLAS) will compare the effectiveness of a patient-versus physician-led initiation of insulin glargine-based basal management in the specific setting of Asia and Russia (as is routinely used in Western countries). This report presents the study design of ATLAS. Methods: Subjects are 40-75 years old (body mass index >= 20 and >= 40 kg/m(2)) with type 2 diabetes mellitus (T2DM) of >2 years in duration, suboptimally controlled (hemoglobin A1c [HbA1c] >= 7.0% and

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ER -

Titration of Insulin Glargine in Patients with Type 2 Diabetes Mellitus in Asia: Physician- Versus Patient-Led? Rationale of the Asian Treat to Target Lantus Study (ATLAS)

Abstract

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