The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide

Víctor M Sánchez-Pedregal, Karel Kubicek, Jens Meiler, Isabelle Lyothier, Ian Paterson, Teresa Carlomagno

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)7388-94
Number of pages7
JournalAngewandte Chemie (International Edition)
Volume45
Issue number44
DOIs
Publication statusPublished - 13 Nov 2006

Keywords

  • Alkanes/chemistry
  • Carbamates/chemistry
  • Epothilones/chemistry
  • Lactones/chemistry
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Molecular Conformation
  • Protein Binding
  • Pyrones/chemistry
  • Solutions/chemistry
  • Tubulin/chemistry

Cite this