The role of triacylglycerols and repurposing DGAT1 inhibitors for the treatment of Mycobacterium tuberculosis

Alice R Moorey; Gurdyal S Besra

doi:10.1016/j.tcsw.2022.100083

The role of triacylglycerols and repurposing DGAT1 inhibitors for the treatment of Mycobacterium tuberculosis

Alice R Moorey, Gurdyal S Besra^*

^*Corresponding author for this work

Biosciences

Research output: Contribution to journal › Review article › peer-review

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Abstract

Latent tuberculosis poses a significant threat to global health through the incubation of undiagnosed infections within the community, and through its tolerance to antibiotics. This Special Features article explores the mechanisms by which the dormant Mycobacterium tuberculosis pathogen can store energy in the form of lipid inclusion bodies and triacylglycerols, which may be key in the development of novel therapeutics to treat TB.

Original language	English
Article number	100083
Number of pages	4
Journal	The Cell Surface
Volume	8
Early online date	15 Oct 2022
DOIs	https://doi.org/10.1016/j.tcsw.2022.100083
Publication status	Published - Dec 2022

Bibliographical note

Keywords

Mycobacterium tuberculosis
Triacylglycerols
Tgs

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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MooreyA2022roleFinal published version, 1.09 MBLicence: Creative Commons: Attribution (CC BY)

Cite this

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abstract = "Latent tuberculosis poses a significant threat to global health through the incubation of undiagnosed infections within the community, and through its tolerance to antibiotics. This Special Features article explores the mechanisms by which the dormant Mycobacterium tuberculosis pathogen can store energy in the form of lipid inclusion bodies and triacylglycerols, which may be key in the development of novel therapeutics to treat TB. ",

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AU - Besra, Gurdyal S

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N2 - Latent tuberculosis poses a significant threat to global health through the incubation of undiagnosed infections within the community, and through its tolerance to antibiotics. This Special Features article explores the mechanisms by which the dormant Mycobacterium tuberculosis pathogen can store energy in the form of lipid inclusion bodies and triacylglycerols, which may be key in the development of novel therapeutics to treat TB.

AB - Latent tuberculosis poses a significant threat to global health through the incubation of undiagnosed infections within the community, and through its tolerance to antibiotics. This Special Features article explores the mechanisms by which the dormant Mycobacterium tuberculosis pathogen can store energy in the form of lipid inclusion bodies and triacylglycerols, which may be key in the development of novel therapeutics to treat TB.

KW - Mycobacterium tuberculosis

KW - Triacylglycerols

KW - Tgs

U2 - 10.1016/j.tcsw.2022.100083

DO - 10.1016/j.tcsw.2022.100083

M3 - Review article

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SN - 2468-2330

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JO - The Cell Surface

JF - The Cell Surface

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The role of triacylglycerols and repurposing DGAT1 inhibitors for the treatment of Mycobacterium tuberculosis

Abstract

Bibliographical note

Keywords

UN SDGs

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Cite this