Abstract
Background: Novel genes and their implications towards different facets of medicine are all the rage in today’s scientific community. This investigation was conducted to ascertain the effects of these genetic sequences on the regeneration potential of axons that were damaged due to injury to the central nervous system (CNS).
Methods: Articles relevant to our aims and objectives were scoured across different online databases from the year 2018 onwards to provide an updated view in this regard.
Results: 9 studies were selected after application of the requisite selection criterion. The studies mainly used mice as subjects, while one evaluated the effects on sea lampreys and African clawed frog species. The analysis included studies reporting the noticeable vs negligible effects of genetic sequences on axon regeneration, with an overall odds ratio (OR) of 0.52 (95% CI: 0.45, 0.60) and a statistically significant difference between the groups (Z = 8.84, P < 0.00001). A relative risk of 0.60 and a 95% confidence interval of 0.54 to 0.68 was also obtained. There was no significant heterogeneity between the studies, indicating that the effect size was consistent across the studies.
Conclusion: The results showed that different proteins were coded for different injury models, indicating that genetic sequences play a noticeable role in the ability of axons to regenerate after CNS injury. However, considering the limitations of our study, the need for more such statistical analysis using different genetic examples is warranted.
Methods: Articles relevant to our aims and objectives were scoured across different online databases from the year 2018 onwards to provide an updated view in this regard.
Results: 9 studies were selected after application of the requisite selection criterion. The studies mainly used mice as subjects, while one evaluated the effects on sea lampreys and African clawed frog species. The analysis included studies reporting the noticeable vs negligible effects of genetic sequences on axon regeneration, with an overall odds ratio (OR) of 0.52 (95% CI: 0.45, 0.60) and a statistically significant difference between the groups (Z = 8.84, P < 0.00001). A relative risk of 0.60 and a 95% confidence interval of 0.54 to 0.68 was also obtained. There was no significant heterogeneity between the studies, indicating that the effect size was consistent across the studies.
Conclusion: The results showed that different proteins were coded for different injury models, indicating that genetic sequences play a noticeable role in the ability of axons to regenerate after CNS injury. However, considering the limitations of our study, the need for more such statistical analysis using different genetic examples is warranted.
| Original language | English |
|---|---|
| Pages (from-to) | e277-e288 |
| Number of pages | 12 |
| Journal | Journal of Population Therapeutics and Clinical Pharmacology |
| Volume | 30 |
| Issue number | 14 |
| Early online date | 7 May 2023 |
| DOIs | |
| Publication status | Published - 9 Jun 2023 |