TY - JOUR
T1 - The response of macrophages to Moraxella catarrhalis infection
AU - Ackland, Jodie
AU - Wallington, Joshua
AU - Cleary, David
AU - Christodoulides, Myron
AU - Staples, Karl
N1 - M1 - PA4127
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Infection by certain bacterial species can predispose an individual to developing asthma and trigger asthmatic exacerbations. Moraxella catarrhalis is one such organism, yet there is little data on the innate immune responses to this pathogen. Alveolar macrophages are the predominant immune cell isolated from the airway and show phenotypic differences in health and asthma. Macrophages are crucial in the immune response by pathogen recognition receptor (PRR)mediated detection of organisms, release of pro-inflammatory mediators and presentation of antigens to other cells of the immune system to link the innate and adaptive immune response. The aim of this work was to investigate the response of macrophages to M.catarrhalis. Monocyte-derived macrophages (MDM) were exposed to M.catarrhalis for 2h, incubated with antiobiotics for 22h before analysis at 24h. The expression of PRRs were analysed by real time PCR. A significant increase of retinoic acid-inducible gene(RIG)I expression(p
AB - Infection by certain bacterial species can predispose an individual to developing asthma and trigger asthmatic exacerbations. Moraxella catarrhalis is one such organism, yet there is little data on the innate immune responses to this pathogen. Alveolar macrophages are the predominant immune cell isolated from the airway and show phenotypic differences in health and asthma. Macrophages are crucial in the immune response by pathogen recognition receptor (PRR)mediated detection of organisms, release of pro-inflammatory mediators and presentation of antigens to other cells of the immune system to link the innate and adaptive immune response. The aim of this work was to investigate the response of macrophages to M.catarrhalis. Monocyte-derived macrophages (MDM) were exposed to M.catarrhalis for 2h, incubated with antiobiotics for 22h before analysis at 24h. The expression of PRRs were analysed by real time PCR. A significant increase of retinoic acid-inducible gene(RIG)I expression(p
U2 - 10.1183/1393003.congress-2017.PA4127
DO - 10.1183/1393003.congress-2017.PA4127
M3 - Article
SN - 0903-1936
VL - 50
JO - European Respiratory Journal
JF - European Respiratory Journal
IS - Suppl 61
ER -