TY - JOUR
T1 - The outcomes measured and reported in observational studies of incidental and untreated intracranial meningioma: A systematic review
AU - Millward, Christopher P
AU - Islim, Abdurrahman I
AU - Armstrong, Terri S
AU - Barrington, Heather
AU - Bell, Sabrina
AU - Brodbelt, Andrew R
AU - Bulbeck, Helen
AU - Dirven, Linda
AU - Grundy, Paul L
AU - Javadpour, Mohsen
AU - Keshwara, Sumirat M
AU - Koszdin, Shelli D
AU - Marson, Anthony G
AU - McDermott, Michael W
AU - Meling, Torstein R
AU - Oliver, Kathy
AU - Plaha, Puneet
AU - Preusser, Matthias
AU - Santarius, Thomas
AU - Srikandarajah, Nisaharan
AU - Taphoorn, Martin J B
AU - Turner, Carole
AU - Watts, Colin
AU - Weller, Michael
AU - Williamson, Paula R
AU - Zadeh, Gelareh
AU - Zamanipoor Najafabadi, Amir H
AU - Jenkinson, Michael D
AU - EORTC BTG, ICOM, EANO, SNO, RANO-PRO, BNOS, SBNS, BIMS, TBTC, International Brain Tumour Alliance, Brainstrust, and Brain Tumour Foundation of Canada
N1 - Funding
This work was supported by The Brain Tumour Charity to complete The COSMIC Project grant: “Deciphering the genetic and epigenetic landscape of clinically aggressive meningiomas” awarded to G.Z. and M.D.J. [Jxr30103 to C.P.M].
PY - 2024
Y1 - 2024
N2 - Background: The clinical management of patients with incidental intracranial meningioma varies markedly and is often based on clinician choice and observational data. Heterogeneous outcome measurement has likely hampered knowledge progress by preventing comparative analysis of similar cohorts of patients. This systematic review aimed to summarize the outcomes measured and reported in observational studies. Methods: A systematic literature search was performed to identify published full texts describing active monitoring of adult cohorts with incidental and untreated intracranial meningioma (PubMed, EMBASE, MEDLINE, and CINAHL via EBSCO, completed January 24, 2022). Reported outcomes were extracted verbatim, along with an associated definition and method of measurement if provided. Verbatim outcomes were de-duplicated and the resulting unique outcomes were grouped under standardized outcome terms. These were classified using the taxonomy proposed by the “Core Outcome Measures in Effectiveness Trials” (COMET) initiative. Results: Thirty-three published articles and 1 ongoing study were included describing 32 unique studies: study designs were retrospective n = 27 and prospective n = 5. In total, 268 verbatim outcomes were reported, of which 77 were defined. Following de-duplication, 178 unique verbatim outcomes remained and were grouped into 53 standardized outcome terms. These were classified using the COMET taxonomy into 9 outcome domains and 3 core areas. Conclusions: Outcome measurement across observational studies of incidental and untreated intracranial meningioma is heterogeneous. The standardized outcome terms identified will be prioritized through an eDelphi survey and consensus meeting of key stakeholders (including patients), in order to develop a Core Outcome Set for use in future observational studies.
AB - Background: The clinical management of patients with incidental intracranial meningioma varies markedly and is often based on clinician choice and observational data. Heterogeneous outcome measurement has likely hampered knowledge progress by preventing comparative analysis of similar cohorts of patients. This systematic review aimed to summarize the outcomes measured and reported in observational studies. Methods: A systematic literature search was performed to identify published full texts describing active monitoring of adult cohorts with incidental and untreated intracranial meningioma (PubMed, EMBASE, MEDLINE, and CINAHL via EBSCO, completed January 24, 2022). Reported outcomes were extracted verbatim, along with an associated definition and method of measurement if provided. Verbatim outcomes were de-duplicated and the resulting unique outcomes were grouped under standardized outcome terms. These were classified using the taxonomy proposed by the “Core Outcome Measures in Effectiveness Trials” (COMET) initiative. Results: Thirty-three published articles and 1 ongoing study were included describing 32 unique studies: study designs were retrospective n = 27 and prospective n = 5. In total, 268 verbatim outcomes were reported, of which 77 were defined. Following de-duplication, 178 unique verbatim outcomes remained and were grouped into 53 standardized outcome terms. These were classified using the COMET taxonomy into 9 outcome domains and 3 core areas. Conclusions: Outcome measurement across observational studies of incidental and untreated intracranial meningioma is heterogeneous. The standardized outcome terms identified will be prioritized through an eDelphi survey and consensus meeting of key stakeholders (including patients), in order to develop a Core Outcome Set for use in future observational studies.
KW - incidental
KW - COMET
KW - Core Outcome Set
KW - meningioma
KW - outcomes
U2 - 10.1093/noajnl/vdae042
DO - 10.1093/noajnl/vdae042
M3 - Review article
SN - 2632-2498
VL - 6
JO - Neuro-oncology advances
JF - Neuro-oncology advances
IS - 1
M1 - vdae042
ER -