The interrater and test-retest reliability of 3 modalities of quantitative sensory testing in healthy adults and people with chronic low back pain or rheumatoid arthritis

Sophia M Brady, Vasileios Georgopoulos, Jet J C S Veldhuijzen van Zanten, Joan L Duda, George S Metsios, George D Kitas, Sally A M Fenton, David A Walsh, Daniel F McWilliams

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Abstract

INTRODUCTION: Quantitative Sensory Testing (QST) modalities used to assess central pain mechanisms require different protocols in people with different musculoskeletal conditions.

OBJECTIVES: We aimed to explore the possible effects of musculoskeletal diagnosis and test site on QST interrater and test-retest reliability.

METHODS: The study included participants with rheumatoid arthritis (RA, n = 18; QST conducted on lower leg) and low back pain (LBP, n = 25; QST conducted on forearm), plus 45 healthy control participants (n = 20 QST on lower leg and n = 25 QST on forearm). Test-retest reliability was assessed from QST conducted 1 to 3 weeks apart. Quantitative sensory testing modalities used were pressure pain detection threshold (PPT) at a site distant to tissue pathology, temporal summation (TS), and conditioned pain modulation (CPM). Temporal summation was calculated as difference or ratio of single and repeated punctate stimuli and unconditioned thresholds for CPM used single or mean of multiple PPTs. Intraclass correlation coefficients (ICCs) were compared between different subgroups.

RESULTS: High to very high reliability was found for all assessments of PPT and TS across anatomical sites (lower leg and forearm) and participants (healthy, RA, and LBP) (ICC ≥ 0.77 for PPT and ICC ≥ 0.76 for TS). Reliability was higher when TS was calculated as a difference rather than a ratio. Conditioned pain modulation showed no to moderate reliability (ICC = 0.01-0.64) that was similar between leg or forearm, and between healthy people and those with RA or LBP.

CONCLUSION: PPT and TS are transferable tools to quantify pain sensitivity at different testing sites in different musculoskeletal diagnoses. Low apparent reliability of CPM protocols might indicate minute-to-minute dynamic pain modulation.

Original languageEnglish
Article numbere1102
Number of pages11
JournalPAIN Reports
Volume8
Issue number6
Early online date10 Oct 2023
DOIs
Publication statusE-pub ahead of print - 10 Oct 2023

Bibliographical note

Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.

Keywords

  • Quantitative sensory testing
  • Rheumatoid arthritis
  • Low back pain
  • Reliability

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