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Abstract
The physiologic and irreversible process of ageing is accompanied by a wide range of structural and functional shifts at multiple different levels. It is also suggested that variations in the blood concentrations of metabolites, hormones, and micronutrients may play a role in the ageing process. Recently, Singh et al. 1,2 investigated a study on Taurine shortage as a driver and biomarker of ageing and its impact on a healthy lifespan.2 They further proposed that functional abnormalities in numerous organs associated with age-related illnesses have been linked to early-life Taurine insufficiency. Taurine deficiency in the elderly and the possible benefits of Taurine supplements One of the reasons for decreasing Taurine concentration is the loss of endogenous synthesis, which may contribute to the decrease in Taurine levels seen in the elderly. While it was previously believed that the liver was responsible for most Taurine synthesis in humans, new research suggests that other organs or common intermediates may play a larger role. The authors experimented with and analysed a life-span examination of various organisms, for example, mice to assess the impacts of Taurine supplementation. They also analysed after the administration of oral Taurine supplementation in conjunction with other interventions using multi-omics data sets (RNA sequencing, metabolomics etc.) across different species.
Original language | English |
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Pages (from-to) | 86-88 |
Journal | Advances in Biomarker Sciences and Technology |
Volume | 5 |
Early online date | 14 Oct 2023 |
DOIs | |
Publication status | Published - 19 Oct 2023 |
Bibliographical note
FundingThe author acknowledge support from the NIHR Birmingham SRMRC, HYPERMARKER (Grant agreement ID 101095480), and the MRC Heath Data Research UK (HDRUK/CFC/01), an initiative funded by UK Research and Innovation, Department of Health and Social Care (England) and the devolved administrations, and leading medical research charities. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the National Institute for Health Research, the Medical Research Council or the Department of Health.
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Hypermarker: Personalised pharmacometabolomic optimisation of treatment for hypertension
Acharjee, A. (Co-Investigator), Gkoutos, G. (Co-Investigator), Mobley, A. (Co-Investigator) & Kotecha, D. (Principal Investigator)
UKRI Horizon Europe Underwriting – Innovate UK
1/01/23 → 31/12/26
Project: Research