Systemic Lupus Erythematosus: an update for Ophthalmologists

Efrosini Papagiannuli, Benjamin Rhodes, Graham R. Wallace, Caroline Gordon, Philip I. Murray, Alastair K. Denniston

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10 Citations (Scopus)
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Systemic lupus erythematosus (SLE) is a life-threatening multi-system inflammatory condition that may affect almost any part of the eye. We provide an update for the practicing ophthalmologist comprising a systematic review of the recent literature presented in the context of current knowledge of the pathogenesis, diagnosis and treatment of this condition. We review recent advances in the understanding of the influence of genetic and environmental factors on the development of SLE. Recent changes in the diagnostic criteria for SLE are considered. We assess the potential for novel molecular biomarkers to find a clinical application in disease diagnosis and stratification and in the development of therapeutic agents. We discuss limited forms of SLE and their differentiation from other collagen vascular disorders and review recent evidence underlying the use of established and novel therapeutics in this condition, including specific implications regarding monitoring for ocular toxicity associated with antimalarials.
Original languageEnglish
Pages (from-to)65-82
JournalSurvey Ophthalmol
Issue number1
Early online date18 Jul 2015
Publication statusPublished - Jan 2016


  • Systemic Lupus Erythematosus
  • Keratoconjunctivitis sicca
  • Sjogren’s syndrome
  • Lupus Retinopathy


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