Sulfation pathways: Insights into steroid sulfation and desulfation pathways

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Abstract

Sulfation and desulfation pathways represent highly dynamic ways of shuttling, repressing and re-activating steroid hormones, thus controlling their immense biological potency at the very heart of endocrinology. This theme currently experiences growing research interest from various sides, including, but not limited to, novel insights about phospho-adenosine-5'-phosphosulfate synthase and sulfotransferase function and regulation, novel analytics for steroid conjugate detection and quantification. Within this review, we will also define how sulfation pathways are ripe for drug development strategies, which have translational potential to treat a number of conditions, including chronic inflammatory diseases and steroid-dependent cancers.
Original languageEnglish
Pages (from-to)T271–T283
Number of pages13
JournalJournal of Molecular Endocrinology
Volume61
Issue number2
DOIs
Publication statusPublished - 1 Aug 2018

Keywords

  • adrenal hormones
  • androgens
  • DHEA
  • hormone action
  • steroid homones

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