Structure determination of a steroid directly from powder diffraction data

Benson M. Kariuki, Katerina Psallidas, Kenneth D.M. Harris*, Roy L. Johnston, Robert W. Lancaster, Susan E. Staniforth, Simon M. Cooper

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)


We report the determination of the crystal structure of a new polymorph of the pharmaceutical material fluticasone propionate, which is obtained as a microcrystalline powder by a supercritical crystallization procedure; the structure was solved directly from powder diffraction data using our Genetic Algorithm technique (in which a population of trial structures evolves through well-defined procedures for mating, mutation and natural selection) and refined using Rietveld refinement techniques.

Original languageEnglish
Pages (from-to)1677-1678
Number of pages2
JournalChemical Communications
Issue number17
Publication statusPublished - 7 Sept 1999

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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