Stereoselective synthesis of 2-dienyl-substituted pyrrolodines using an eta(4)-dienetricarbonyliron complex as the stereodirecting element: elaboration to the pyrrolozidine skeleton

Iwan Williams; Benson Kariuki; K Reeves; Liam Cox

Stereoselective synthesis of 2-dienyl-substituted pyrrolodines using an eta(4)-dienetricarbonyliron complex as the stereodirecting element: elaboration to the pyrrolozidine skeleton

Iwan Williams, Benson Kariuki, K Reeves, Liam Cox

Chemistry

Research output: Contribution to journal › Article

Abstract

Primary amines react with keto-aldehyde functionality located in the side-chain of an eta(4)-dienetricarbonyliron complex to provide the corresponding pyrrolidines in excellent diastereoselectivity. Two of the pyrrolidine products, 1i and 1k, have been elaborated into pyrrolizidines using a 1,5-C-H insertion and radical cyclization strategy, respectively.

Original language	English
Pages (from-to)	4389-4392
Number of pages	4
Journal	Organic Letters
Volume	8
Issue number	20
Publication status	Published - 1 Jan 2006

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title = "Stereoselective synthesis of 2-dienyl-substituted pyrrolodines using an eta(4)-dienetricarbonyliron complex as the stereodirecting element: elaboration to the pyrrolozidine skeleton",

abstract = "Primary amines react with keto-aldehyde functionality located in the side-chain of an eta(4)-dienetricarbonyliron complex to provide the corresponding pyrrolidines in excellent diastereoselectivity. Two of the pyrrolidine products, 1i and 1k, have been elaborated into pyrrolizidines using a 1,5-C-H insertion and radical cyclization strategy, respectively.",

author = "Iwan Williams and Benson Kariuki and K Reeves and Liam Cox",

year = "2006",

month = jan,

day = "1",

language = "English",

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pages = "4389--4392",

journal = "Organic Letters",

publisher = "American Chemical Society",

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T1 - Stereoselective synthesis of 2-dienyl-substituted pyrrolodines using an eta(4)-dienetricarbonyliron complex as the stereodirecting element: elaboration to the pyrrolozidine skeleton

AU - Williams, Iwan

AU - Kariuki, Benson

AU - Reeves, K

AU - Cox, Liam

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Primary amines react with keto-aldehyde functionality located in the side-chain of an eta(4)-dienetricarbonyliron complex to provide the corresponding pyrrolidines in excellent diastereoselectivity. Two of the pyrrolidine products, 1i and 1k, have been elaborated into pyrrolizidines using a 1,5-C-H insertion and radical cyclization strategy, respectively.

AB - Primary amines react with keto-aldehyde functionality located in the side-chain of an eta(4)-dienetricarbonyliron complex to provide the corresponding pyrrolidines in excellent diastereoselectivity. Two of the pyrrolidine products, 1i and 1k, have been elaborated into pyrrolizidines using a 1,5-C-H insertion and radical cyclization strategy, respectively.

M3 - Article

VL - 8

SP - 4389

EP - 4392

JO - Organic Letters

JF - Organic Letters

IS - 20

ER -

Stereoselective synthesis of 2-dienyl-substituted pyrrolodines using an eta(4)-dienetricarbonyliron complex as the stereodirecting element: elaboration to the pyrrolozidine skeleton

Abstract

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