Stereoselective synthesis of 2-dienyl-substituted piperidines using an η 4-dienetricarbonyliron complex as the stereocontrolling element in a double reductive amination cascade

Keyphrases

• Aldehydes 100%
• Stereoselective Synthesis 100%
• Reductive Amination 100%
• Substituted piperidines 100%
• Cyclization 66%
• Keto 66%
• Excellent Yields 66%
• Primary Amines 33%
• Side Chain 33%
• X-ray Crystallography 33%
• Piperidine 33%
• Stereoselectivity 33%
• Ring Systems 33%
• Copper Chloride 33%
• Cascade Process 33%
• Complete Control 33%
• Stereoinduction 33%
• Azepane 33%
• Chiral Auxiliary 33%
• Complex Function 33%
• Keto-amine 33%

Chemistry

• Piperidine 100%
• Stereoselective Synthesis 100%
• Reductive Amination 100%
• formation 33%
• X-Ray Crystallography 33%
• Stereoselectivity 33%
• Cyclic Structure 33%
• Primary Amine 33%
• Chiral Auxiliary 33%
• Azepane 33%