Standardised definitions and diagnostic criteria for extra nodal extension on histopathological examination in head and neck cancer: HNCIG international consensus recommendations

Ahmad Abou-Foul; Christina Henson; Max Robinson; Rebecca D. Chernock; Shao Hui Huang; William M. Lydiatt; Lachlan Mcdowell; Brian O'Sullivan; Bayardo Perez-Ordonez; Paul Nankivell; Elena Ruiz-Bravo; Simion Chiosea; Tina M. McGreen; Keith D. Hunter; Jaqueline S. G. Hwang; Senada Koljenovic; Sjors A. Koppes; Stine R. Larsen; Anthony Wi Lo; Valérie Costes-Martineau; Neha Mittal; Toshitaka Mori; Ioannis G. Panayiotides; Clóvis A. L.  Pinto; Kathrin Scheckenbach; Raja R. Seethala; Benedicte P.  Ulhøi; Andrea Vingiani; Yan Zhang; Sue S. Yam; Hisham Mehanna

Standardised definitions and diagnostic criteria for extra nodal extension on histopathological examination in head and neck cancer: HNCIG international consensus recommendations

Ahmad Abou-Foul, Christina Henson, Max Robinson, Rebecca D. Chernock, Shao Hui Huang, William M. Lydiatt, Lachlan Mcdowell, Brian O'Sullivan, Bayardo Perez-Ordonez, Paul Nankivell, Elena Ruiz-Bravo, Simion Chiosea, Tina M. McGreen, Keith D. Hunter, Jaqueline S. G. Hwang, Senada Koljenovic, Sjors A. Koppes, Stine R. Larsen, Anthony Wi Lo, Valérie Costes-MartineauNeha Mittal, Toshitaka Mori, Ioannis G. Panayiotides, Clóvis A. L. Pinto, Kathrin Scheckenbach, Raja R. Seethala, Benedicte P. Ulhøi, Andrea Vingiani, Yan Zhang, Sue S. Yam, Hisham Mehanna^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Detection of extranodal extension on histopathology (pENE) in surgically treated head and neck squamous cell carcinoma (HNSCC) indicates poor prognosis. However, there is no consensus on the diagnostic criteria, interpretation and reporting pENE, which has contributed to conflicting evidence in the literature, and likely inconsistency clinically. The Head and Neck Cancer International Group conducted a three-round modified Delphi process with a group of 19 international pathology experts, representing 15 national clinical research groups, to generate consensus recommendations for pENE diagnostic criteria. The expert panel achieved strong agreement on terminology and diagnostic features for pENE and soft tissue metastasis. Moreover, the panel reached consensus on reporting of pENE and on nodal sampling.
These consensus recommendations, endorsed by 19 organisations representing 34 countries, are a critical development towards more standardised diagnosis and reporting of pENE, and more accurate data collection and analysis.

Original language	English
Journal	The Lancet Oncology
Publication status	Accepted/In press - 7 Mar 2024

Bibliographical note

Not yet published as of 22/04/2024.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Abou-Foul, A., Henson, C., Robinson, M., Chernock, R. D., Huang, S. H., Lydiatt, W. M., Mcdowell, L., O'Sullivan, B., Perez-Ordonez, B., Nankivell, P., Ruiz-Bravo, E., Chiosea, S., McGreen, T. M., Hunter, K. D., Hwang, J. S. G., Koljenovic, S., Koppes, S. A., Larsen, S. R., Lo, A. W., ... Mehanna, H. (Accepted/In press). Standardised definitions and diagnostic criteria for extra nodal extension on histopathological examination in head and neck cancer: HNCIG international consensus recommendations. The Lancet Oncology.

@article{41e9152723ae40398ef3f29057d2644a,

title = "Standardised definitions and diagnostic criteria for extra nodal extension on histopathological examination in head and neck cancer: HNCIG international consensus recommendations",

abstract = "Detection of extranodal extension on histopathology (pENE) in surgically treated head and neck squamous cell carcinoma (HNSCC) indicates poor prognosis. However, there is no consensus on the diagnostic criteria, interpretation and reporting pENE, which has contributed to conflicting evidence in the literature, and likely inconsistency clinically. The Head and Neck Cancer International Group conducted a three-round modified Delphi process with a group of 19 international pathology experts, representing 15 national clinical research groups, to generate consensus recommendations for pENE diagnostic criteria. The expert panel achieved strong agreement on terminology and diagnostic features for pENE and soft tissue metastasis. Moreover, the panel reached consensus on reporting of pENE and on nodal sampling.These consensus recommendations, endorsed by 19 organisations representing 34 countries, are a critical development towards more standardised diagnosis and reporting of pENE, and more accurate data collection and analysis.",

author = "Ahmad Abou-Foul and Christina Henson and Max Robinson and Chernock, {Rebecca D.} and Huang, {Shao Hui} and Lydiatt, {William M.} and Lachlan Mcdowell and Brian O'Sullivan and Bayardo Perez-Ordonez and Paul Nankivell and Elena Ruiz-Bravo and Simion Chiosea and McGreen, {Tina M.} and Hunter, {Keith D.} and Hwang, {Jaqueline S. G.} and Senada Koljenovic and Koppes, {Sjors A.} and Larsen, {Stine R.} and Lo, {Anthony Wi} and Val{\'e}rie Costes-Martineau and Neha Mittal and Toshitaka Mori and Panayiotides, {Ioannis G.} and Pinto, {Cl{\'o}vis A. L.} and Kathrin Scheckenbach and Seethala, {Raja R.} and Ulh{\o}i, {Benedicte P.} and Andrea Vingiani and Yan Zhang and Yam, {Sue S.} and Hisham Mehanna",

note = "Not yet published as of 22/04/2024.",

year = "2024",

month = mar,

day = "7",

language = "English",

journal = "The Lancet Oncology",

issn = "1470-2045",

publisher = "Elsevier",

}

Abou-Foul, A, Henson, C, Robinson, M, Chernock, RD, Huang, SH, Lydiatt, WM, Mcdowell, L, O'Sullivan, B, Perez-Ordonez, B, Nankivell, P, Ruiz-Bravo, E, Chiosea, S, McGreen, TM, Hunter, KD, Hwang, JSG, Koljenovic, S, Koppes, SA, Larsen, SR, Lo, AW, Costes-Martineau, V, Mittal, N, Mori, T, Panayiotides, IG, Pinto, CAL, Scheckenbach, K, Seethala, RR, Ulhøi, BP, Vingiani, A, Zhang, Y, Yam, SS & Mehanna, H 2024, 'Standardised definitions and diagnostic criteria for extra nodal extension on histopathological examination in head and neck cancer: HNCIG international consensus recommendations', The Lancet Oncology.

TY - JOUR

T1 - Standardised definitions and diagnostic criteria for extra nodal extension on histopathological examination in head and neck cancer

T2 - HNCIG international consensus recommendations

AU - Abou-Foul, Ahmad

AU - Henson, Christina

AU - Robinson, Max

AU - Chernock, Rebecca D.

AU - Huang, Shao Hui

AU - Lydiatt, William M.

AU - Mcdowell, Lachlan

AU - O'Sullivan, Brian

AU - Perez-Ordonez, Bayardo

AU - Nankivell, Paul

AU - Ruiz-Bravo, Elena

AU - Chiosea, Simion

AU - McGreen, Tina M.

AU - Hunter, Keith D.

AU - Hwang, Jaqueline S. G.

AU - Koljenovic, Senada

AU - Koppes, Sjors A.

AU - Larsen, Stine R.

AU - Lo, Anthony Wi

AU - Costes-Martineau, Valérie

AU - Mittal, Neha

AU - Mori, Toshitaka

AU - Panayiotides, Ioannis G.

AU - Pinto, Clóvis A. L.

AU - Scheckenbach, Kathrin

AU - Seethala, Raja R.

AU - Ulhøi, Benedicte P.

AU - Vingiani, Andrea

AU - Zhang, Yan

AU - Yam, Sue S.

AU - Mehanna, Hisham

N1 - Not yet published as of 22/04/2024.

PY - 2024/3/7

Y1 - 2024/3/7

N2 - Detection of extranodal extension on histopathology (pENE) in surgically treated head and neck squamous cell carcinoma (HNSCC) indicates poor prognosis. However, there is no consensus on the diagnostic criteria, interpretation and reporting pENE, which has contributed to conflicting evidence in the literature, and likely inconsistency clinically. The Head and Neck Cancer International Group conducted a three-round modified Delphi process with a group of 19 international pathology experts, representing 15 national clinical research groups, to generate consensus recommendations for pENE diagnostic criteria. The expert panel achieved strong agreement on terminology and diagnostic features for pENE and soft tissue metastasis. Moreover, the panel reached consensus on reporting of pENE and on nodal sampling.These consensus recommendations, endorsed by 19 organisations representing 34 countries, are a critical development towards more standardised diagnosis and reporting of pENE, and more accurate data collection and analysis.

AB - Detection of extranodal extension on histopathology (pENE) in surgically treated head and neck squamous cell carcinoma (HNSCC) indicates poor prognosis. However, there is no consensus on the diagnostic criteria, interpretation and reporting pENE, which has contributed to conflicting evidence in the literature, and likely inconsistency clinically. The Head and Neck Cancer International Group conducted a three-round modified Delphi process with a group of 19 international pathology experts, representing 15 national clinical research groups, to generate consensus recommendations for pENE diagnostic criteria. The expert panel achieved strong agreement on terminology and diagnostic features for pENE and soft tissue metastasis. Moreover, the panel reached consensus on reporting of pENE and on nodal sampling.These consensus recommendations, endorsed by 19 organisations representing 34 countries, are a critical development towards more standardised diagnosis and reporting of pENE, and more accurate data collection and analysis.

UR - https://www.thelancet.com/journals/lanonc/issue/current

M3 - Article

SN - 1470-2045

JO - The Lancet Oncology

JF - The Lancet Oncology

ER -

Standardised definitions and diagnostic criteria for extra nodal extension on histopathological examination in head and neck cancer: HNCIG international consensus recommendations

Abstract

Bibliographical note

UN SDGs

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