Stabilization of Polycation-DNA Complexes by Surface Modification with Hydrophilic Polymers

D Oupicky; M L Read; T Bettinger

doi:10.1385/1-59259-139-6:61

Stabilization of Polycation-DNA Complexes by Surface Modification with Hydrophilic Polymers

D Oupicky, M L Read, T Bettinger

Research output: Contribution to journal › Article › peer-review

Abstract

Polycation-DNA complexes represent promising synthetic vectors for gene delivery, showing good transfection activities in vitro and safety in vivo. However, simple polycation-DNA complexes suffer from several disadvantages that limit their potential usefulness in vivo. Advances in this field thus rely on better control of the structure, colloidal, and surface properties of condensed DNA particles.

Original language	English
Pages (from-to)	61-78
Number of pages	18
Journal	Methods in Molecular Medicine
Volume	65
DOIs	https://doi.org/10.1385/1-59259-139-6:61
Publication status	Published - 2001

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title = "Stabilization of Polycation-DNA Complexes by Surface Modification with Hydrophilic Polymers",

abstract = "Polycation-DNA complexes represent promising synthetic vectors for gene delivery, showing good transfection activities in vitro and safety in vivo. However, simple polycation-DNA complexes suffer from several disadvantages that limit their potential usefulness in vivo. Advances in this field thus rely on better control of the structure, colloidal, and surface properties of condensed DNA particles.",

author = "D Oupicky and Read, {M L} and T Bettinger",

year = "2001",

doi = "10.1385/1-59259-139-6:61",

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AU - Oupicky, D

AU - Read, M L

AU - Bettinger, T

PY - 2001

Y1 - 2001

N2 - Polycation-DNA complexes represent promising synthetic vectors for gene delivery, showing good transfection activities in vitro and safety in vivo. However, simple polycation-DNA complexes suffer from several disadvantages that limit their potential usefulness in vivo. Advances in this field thus rely on better control of the structure, colloidal, and surface properties of condensed DNA particles.

AB - Polycation-DNA complexes represent promising synthetic vectors for gene delivery, showing good transfection activities in vitro and safety in vivo. However, simple polycation-DNA complexes suffer from several disadvantages that limit their potential usefulness in vivo. Advances in this field thus rely on better control of the structure, colloidal, and surface properties of condensed DNA particles.

U2 - 10.1385/1-59259-139-6:61

DO - 10.1385/1-59259-139-6:61

M3 - Article

C2 - 21318745

SN - 1543-1894

VL - 65

SP - 61

EP - 78

JO - Methods in Molecular Medicine

JF - Methods in Molecular Medicine

ER -

Stabilization of Polycation-DNA Complexes by Surface Modification with Hydrophilic Polymers

Abstract

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