Projects per year
Abstract
The behavior of vascular EC is greatly altered in sites of pathological angiogenesis, such as a developing tumor or atherosclerotic plaque. Until recently it was thought that this was largely due to abnormal chemical signaling, i.e., endothelial cell chemo transduction, at these sites. However, we now demonstrate that the shear stress intensity encountered by EC can have a profound impact on their gene expression and behavior. We review the growing body of evidence suggesting that mechanotransduction, too, is a major regulator of pathological angiogenesis. This fits with the evolving story of physiological angiogenesis, where a combination of metabolic and mechanical signaling is emerging as the probable mechanism by which tight feedback regulation of angiogenesis is achieved in vivo.
Original language | English |
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Pages (from-to) | 290-300 |
Number of pages | 11 |
Journal | Microcirculation |
Volume | 21 |
Issue number | 4 |
Early online date | 28 Jan 2014 |
DOIs | |
Publication status | Published - May 2014 |
Bibliographical note
© 2014 John Wiley & Sons Ltd.Fingerprint
Dive into the research topics of 'Shear stress regulated gene expression and angiogenesis in vascular endothelium'. Together they form a unique fingerprint.Projects
- 1 Finished
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The Role of Platelet Surface Receptors in Angiogenesis
Egginton, S. (Principal Investigator), Bicknell, R. (Co-Investigator) & Watson, S. (Co-Investigator)
6/10/08 → 5/01/12
Project: Research