Shear stress regulated gene expression and angiogenesis in vascular endothelium

Joseph W. Wragg, Sarah Durant, Helen M McGettrick, Klarke M Sample, Stuart Egginton, Roy Bicknell

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)


The behavior of vascular EC is greatly altered in sites of pathological angiogenesis, such as a developing tumor or atherosclerotic plaque. Until recently it was thought that this was largely due to abnormal chemical signaling, i.e., endothelial cell chemo transduction, at these sites. However, we now demonstrate that the shear stress intensity encountered by EC can have a profound impact on their gene expression and behavior. We review the growing body of evidence suggesting that mechanotransduction, too, is a major regulator of pathological angiogenesis. This fits with the evolving story of physiological angiogenesis, where a combination of metabolic and mechanical signaling is emerging as the probable mechanism by which tight feedback regulation of angiogenesis is achieved in vivo.
Original languageEnglish
Pages (from-to)290-300
Number of pages11
Issue number4
Early online date28 Jan 2014
Publication statusPublished - May 2014

Bibliographical note

© 2014 John Wiley & Sons Ltd.


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