Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans

Stephen Butcher; Hemalata Chahal; L Nayak; Alan Sinclair; Nico Henriquez; Elizabeth Sapey; D O'Mahony; Janet Lord

Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans

Stephen Butcher, Hemalata Chahal, L Nayak, Alan Sinclair, Nico Henriquez, Elizabeth Sapey, D O'Mahony, Janet Lord

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Abstract

Elderly humans are more susceptible to bacterial infections because of declining immune status. We have investigated the effect of aging on neutrophil bactericidal responses, comparing neutrophil function in healthy, young (23-35 years) and elderly (>65 years) volunteers. Superoxide generation in response to fMLP was slightly increased in neutrophils from elderly donors, and serum from the elderly was able to opsonize E. coli efficiently. In contrast, phagocytic index was significantly lower in neutrophils from the elderly, compared with young donors (P

Original language	English
Pages (from-to)	881-886
Number of pages	6
Journal	Journal of Leukocyte Biology
Volume	70
Issue number	6
Publication status	Published - 1 Dec 2001

Keywords

immunesenescence
neutrophil-function
aging

Cite this

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title = "Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans",

abstract = "Elderly humans are more susceptible to bacterial infections because of declining immune status. We have investigated the effect of aging on neutrophil bactericidal responses, comparing neutrophil function in healthy, young (23-35 years) and elderly (>65 years) volunteers. Superoxide generation in response to fMLP was slightly increased in neutrophils from elderly donors, and serum from the elderly was able to opsonize E. coli efficiently. In contrast, phagocytic index was significantly lower in neutrophils from the elderly, compared with young donors (P",

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T1 - Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans

AU - Butcher, Stephen

AU - Chahal, Hemalata

AU - Nayak, L

AU - Sinclair, Alan

AU - Henriquez, Nico

AU - Sapey, Elizabeth

AU - O'Mahony, D

AU - Lord, Janet

PY - 2001/12/1

Y1 - 2001/12/1

N2 - Elderly humans are more susceptible to bacterial infections because of declining immune status. We have investigated the effect of aging on neutrophil bactericidal responses, comparing neutrophil function in healthy, young (23-35 years) and elderly (>65 years) volunteers. Superoxide generation in response to fMLP was slightly increased in neutrophils from elderly donors, and serum from the elderly was able to opsonize E. coli efficiently. In contrast, phagocytic index was significantly lower in neutrophils from the elderly, compared with young donors (P

AB - Elderly humans are more susceptible to bacterial infections because of declining immune status. We have investigated the effect of aging on neutrophil bactericidal responses, comparing neutrophil function in healthy, young (23-35 years) and elderly (>65 years) volunteers. Superoxide generation in response to fMLP was slightly increased in neutrophils from elderly donors, and serum from the elderly was able to opsonize E. coli efficiently. In contrast, phagocytic index was significantly lower in neutrophils from the elderly, compared with young donors (P

KW - immunesenescence

KW - neutrophil-function

KW - aging

M3 - Article

VL - 70

SP - 881

EP - 886

JO - Journal of Leukocyte Biology

JF - Journal of Leukocyte Biology

IS - 6

ER -

Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans

Abstract

Keywords

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