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Abstract
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive lethal diseases among other cancer types. Gut microbiome and its metabolic regulation play a crucial role in PDAC. Metabolic regulation in the gut is a complex process that involves microbiome and microbiome-derived short-chain fatty acids (SCFAs). SCFAs regulate inflammation, as well as lipid and glucose metabolism, through different pathways. This review aims to summarize recent developments in PDAC in the context of gut and oral microbiota and their associations with short-chain fatty acid (SCFA). In addition to this, we discuss possible therapeutic applications using microbiota in PDAC.
Original language | English |
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Journal | Cancer Medicine |
Early online date | 7 Oct 2022 |
DOIs | |
Publication status | E-pub ahead of print - 7 Oct 2022 |
Bibliographical note
Funding Information:This work was funded by MRC Health Data Research UK (HDRUK/CFC/01), an initiative funded by UK Research and Innovation, Department of Health and Social Care (England) and the devolved administrations, and leading medical research charities. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the National Institute for Health Research, the Medical Research Council or the Department of Health. Animesh Acharjee and Georgios V. Gkoutos also acknowledge support from the NIHR Birmingham SRMRC, Nanocommons H2020‐EU (731032) and MAESTRIA (Grant agreement ID 965286).
Publisher Copyright:
© 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Keywords
- SCFA
- host–microbe interactions
- inflammation
- microbiome
- microbiota
- pancreatic ductal adenocarcinoma
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Cancer Research
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Dive into the research topics of 'Role of microbiota and microbiota-derived short-chain fatty acids in PDAC'. Together they form a unique fingerprint.Projects
- 1 Finished
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H2020_RIA_NANOCOMMONS_CO-ORDINATOR
Valsami-Jones, E. (Co-Investigator), Lynch, I. (Principal Investigator) & Gkoutos, G. (Co-Investigator)
1/01/18 → 30/06/22
Project: EU