Role of B-cell receptors for B-cell development and antigen-induced differentiation

Juan Carlos Yam-Puc*, Lingling Zhang, Yang Zhang, Kai Michael Toellner

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)
204 Downloads (Pure)

Abstract

B-cell development is characterized by a number of tightly regulated selection processes. Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1, marginal zone, and peripheral follicular B cells. Furthermore, we discuss BCR-derived signals on activated B cells that lead to germinal center and plasma cell differentiation.

Original languageEnglish
Article number429
JournalF1000Research
Volume7
DOIs
Publication statusPublished - 6 Apr 2018

Keywords

  • B cell development
  • B cell differentiation
  • B cell receptor

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • Medicine (miscellaneous)

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