TY - JOUR
T1 - Risk factors for obesity in childhood survivors of suprasellar brain tumours
T2 - A retrospective study
AU - Lek, Ngee
AU - Prentice, Philippa
AU - Williams, Rachel M.
AU - Ong, Ken K.
AU - Burke, Gladstone Austin Amos
AU - Acerini, Carlo L.
PY - 2010/10
Y1 - 2010/10
N2 - Aim: To characterize postdiagnosis changes in body mass index (BMI) among childhood survivors of suprasellar brain tumours, and to determine the risk factors associated with obesity. Methods: We conducted a retrospective analysis of 46 children (16 boys and 30 girls) with median (IQR) age of 7.49 (3.47-11.59) years at tumour diagnosis, and followed up for 3.93 (1.68-7.27) years. Survival analyses were used to identify risks of developing obesity. Results: There were no sex differences in age at tumour diagnosis, duration of follow-up, tumour types, endocrinopathies, treatment modalities or baseline BMI SDS. In the first year after tumour diagnosis, ΔBMI SDS (median; IQR) was greater in girls (1.32; 0.07-2.08) than in boys (0.48;-0.40 to 0.89) (p = 0.01). At diagnosis, 3/46 children (6%) were obese; this increased to 20/46 (43%) by last follow-up (p < 0.001) and was more common in girls (17/30; 57%) than in boys (3/16; 19%). Female gender (hazard ratio 5.0, 95% CI 1.2-21.7; p = 0.04) and greater than average baseline BMI (hazard ratio 4.7, 95% CI 1.1-20.8; p = 0.02) were risk factors for subsequent obesity. Conclusion: Accurate prediction of obesity risk is important and would allow early targeted intervention in high-risk patients.
AB - Aim: To characterize postdiagnosis changes in body mass index (BMI) among childhood survivors of suprasellar brain tumours, and to determine the risk factors associated with obesity. Methods: We conducted a retrospective analysis of 46 children (16 boys and 30 girls) with median (IQR) age of 7.49 (3.47-11.59) years at tumour diagnosis, and followed up for 3.93 (1.68-7.27) years. Survival analyses were used to identify risks of developing obesity. Results: There were no sex differences in age at tumour diagnosis, duration of follow-up, tumour types, endocrinopathies, treatment modalities or baseline BMI SDS. In the first year after tumour diagnosis, ΔBMI SDS (median; IQR) was greater in girls (1.32; 0.07-2.08) than in boys (0.48;-0.40 to 0.89) (p = 0.01). At diagnosis, 3/46 children (6%) were obese; this increased to 20/46 (43%) by last follow-up (p < 0.001) and was more common in girls (17/30; 57%) than in boys (3/16; 19%). Female gender (hazard ratio 5.0, 95% CI 1.2-21.7; p = 0.04) and greater than average baseline BMI (hazard ratio 4.7, 95% CI 1.1-20.8; p = 0.02) were risk factors for subsequent obesity. Conclusion: Accurate prediction of obesity risk is important and would allow early targeted intervention in high-risk patients.
KW - Body mass index
KW - Obesity
KW - Risk factors
KW - Suprasellar brain tumours
UR - http://www.scopus.com/inward/record.url?scp=77956357923&partnerID=8YFLogxK
U2 - 10.1111/j.1651-2227.2010.01867.x
DO - 10.1111/j.1651-2227.2010.01867.x
M3 - Article
C2 - 20491696
AN - SCOPUS:77956357923
SN - 0803-5253
VL - 99
SP - 1522
EP - 1526
JO - Acta Paediatrica, International Journal of Paediatrics
JF - Acta Paediatrica, International Journal of Paediatrics
IS - 10
ER -