Risk factors associated with endometrial polyps in abnormal uterine bleeding

Shagaf Bakour, Janesh Gupta, Khalid Khan

Research output: Contribution to journalArticle

22 Citations (Scopus)


OBJECTIVES: To evaluate the significance of various risk factors associated with endometrial polyps in women with abnormal uterine bleeding. METHODS: A prospective cohort study of 248 consecutive patients evaluated for abnormal uterine bleeding in a Rapid Access Ambulatory Diagnostic (RAAD) clinic was carried out from 1996 to 1997. Endometrial polyps were diagnosed using outpatient hysteroscopy and their histological nature was confirmed in all patients by performing inpatient polypectomy. Multivariate logistic regression modeling was used to evaluate the effects of age, parity, menopausal status, hormone replacement therapy and tamoxifen treatment on the occurrence of polyps. RESULTS: In an analysis adjusted for the effects of age, parity and menopausal status, tamoxifen treatment was associated with endometrial polyps (adjusted odds ratio 11.21, 95% confidence interval 2.70-46.46, P=0.0009) but hormone replacement therapy was not (adjusted odds ratio 1.48, 95% confidence interval 0.68-3.20, P=0.32). CONCLUSION: Our study confirmed that tamoxifen is associated with endometrial polyps. However, it rejects the hypothesis that hormone replacement therapy is a risk factor for endometrial polyps.
Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalInternational Journal of Gynecology & Obstetrics
Issue number2
Publication statusPublished - 1 Feb 2002


  • tamoxifen
  • endometrial polyps
  • hormone replacement therapy


Dive into the research topics of 'Risk factors associated with endometrial polyps in abnormal uterine bleeding'. Together they form a unique fingerprint.

Cite this