Release of diacylglycerol-enriched vesicles from erythrocytes with increased intracellular [Ca2+]

David Allan; M. M. Billah; J. B. Finean; Robert H. Michell

doi:10.1038/261058a0

Release of diacylglycerol-enriched vesicles from erythrocytes with increased intracellular [Ca2+]

David Allan^*, M. M. Billah, J. B. Finean, Robert H. Michell

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

175 Citations (Scopus)

Abstract

WHEN the intracellular Ca²⁺ concentration of human red cells was increased by treatment of the cells with A23187, a divalent cation ionophore, they changed shape from discocyte to echinocyte^1-3 and the 1,2-diacylglycerol content of their membranes was increased^2-4. In these experiments it seemed that microvesicles budded off from the microvillus-like projections on the echinocytes^2,3. We have now isolated the microvesicles and examined their composition and structure.

Original language	English
Pages (from-to)	58-60
Number of pages	3
Journal	Nature
Volume	261
Issue number	5555
DOIs	https://doi.org/10.1038/261058a0
Publication status	Published - 1 Dec 1976

ASJC Scopus subject areas

General Medicine
General

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abstract = "WHEN the intracellular Ca2+ concentration of human red cells was increased by treatment of the cells with A23187, a divalent cation ionophore, they changed shape from discocyte to echinocyte1-3 and the 1,2-diacylglycerol content of their membranes was increased2-4. In these experiments it seemed that microvesicles budded off from the microvillus-like projections on the echinocytes2,3. We have now isolated the microvesicles and examined their composition and structure.",

author = "David Allan and Billah, {M. M.} and Finean, {J. B.} and Michell, {Robert H.}",

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AU - Allan, David

AU - Billah, M. M.

AU - Finean, J. B.

AU - Michell, Robert H.

PY - 1976/12/1

Y1 - 1976/12/1

N2 - WHEN the intracellular Ca2+ concentration of human red cells was increased by treatment of the cells with A23187, a divalent cation ionophore, they changed shape from discocyte to echinocyte1-3 and the 1,2-diacylglycerol content of their membranes was increased2-4. In these experiments it seemed that microvesicles budded off from the microvillus-like projections on the echinocytes2,3. We have now isolated the microvesicles and examined their composition and structure.

AB - WHEN the intracellular Ca2+ concentration of human red cells was increased by treatment of the cells with A23187, a divalent cation ionophore, they changed shape from discocyte to echinocyte1-3 and the 1,2-diacylglycerol content of their membranes was increased2-4. In these experiments it seemed that microvesicles budded off from the microvillus-like projections on the echinocytes2,3. We have now isolated the microvesicles and examined their composition and structure.

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ER -

Release of diacylglycerol-enriched vesicles from erythrocytes with increased intracellular [Ca2+]

Abstract

ASJC Scopus subject areas

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