Release of diacylglycerol-enriched vesicles from erythrocytes with increased intracellular [Ca2+]

David Allan, M. M. Billah, J. B. Finean, Robert H. Michell

Research output: Contribution to journalArticlepeer-review

175 Citations (Scopus)

Abstract

WHEN the intracellular Ca2+ concentration of human red cells was increased by treatment of the cells with A23187, a divalent cation ionophore, they changed shape from discocyte to echinocyte1-3 and the 1,2-diacylglycerol content of their membranes was increased2-4. In these experiments it seemed that microvesicles budded off from the microvillus-like projections on the echinocytes2,3. We have now isolated the microvesicles and examined their composition and structure.

Original languageEnglish
Pages (from-to)58-60
Number of pages3
JournalNature
Volume261
Issue number5555
DOIs
Publication statusPublished - 1 Dec 1976

ASJC Scopus subject areas

  • Medicine(all)
  • General

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