Relationships between age at diagnosis, clinical features, and outcome of therapy in children treated in the Medical Research Council AML10 and 12 trials for acute myeloid leukemia

Between May 1988 and June 2000, 698 children were treated in the Medical Research Council acute myeloid leukemia 10 and 12 trials. The presenting features and outcomes of therapy in these children were compared by age. Although there was no single cutoff in age, younger children were more likely to have intermediate risk and less likely to have favorable cytogenetics (P