Regular use of proton pump inhibitor and risk of rheumatoid arthritis in women: a prospective cohort study

Jinqiu Yang, Changhua Zhang, Jeffrey Sparks, Susan Malspeis, Kelvin Tsoi, Jean Kim, Benjamin Fisher, Fang Gao Smith, Tim Sumerlin, Yan Liu, Yuxing Liu, Yihang Pan, Yelong He, Joseph Sung

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2 Citations (Scopus)
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Proton pump inhibitors (PPIs) have a significant impact on the gut microbiome, which in turn, might increase the risk of rheumatoid arthritis (RA).


To evaluate regular use of PPIs and risk of RA.


This is a prospective analysis of the US nurses who reported PPI use data, and were free of RA from the Nurses’ Health Study (NHS 2002‐2014) and NHS II (2003‐2015). The exposure was regular use of PPI in the past 2 years, which was repeatedly evaluated in biennial surveys. RA was confirmed by the 1987 or 2010 American College of Rheumatology criteria. We estimated the hazard ratios (HRs) and confidence interval (CIs) with time‐dependent Cox regression adjusting for potential confounders.


We documented 421 cases of RA over 1 753 879 person‐years of follow‐up. Regular PPI users had a 44% higher risk of RA as compared with non‐regular users (adjusted HR = 1.44; 95%CI, 1.10‐1.89). The risk of RA increased with the total duration of PPI use (P‐trend = 0.008). Compared with non‐regular users, the adjusted HRs were 1.22 (95%CI, 0.93‐1.62) for women with >0 to 4 years’ use and 1.73 (95% CI, 1.14 to 2.61) for >4 years’ use.


Regular use of PPI was associated with increased risk of RA in women, with a higher risk observed in individuals with a longer duration of PPI use. Due to the observational study design, large prospective trials are still required to confirm our finding.

Original languageEnglish
Pages (from-to)449-458
JournalAlimentary Pharmacology & Therapeutics
Issue number3
Early online date29 Jun 2020
Publication statusPublished - Aug 2020

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)


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