Reduced cortico-muscular beta coupling in Parkinson's disease predicts motor impairment

Nahid Zokaei*, Andrew J. Quinn, Michele T. Hu, Masud Husain, Freek Van Ede, Anna Christina Nobre

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
33 Downloads (Pure)

Abstract

Long-range communication through the motor system is thought to be facilitated by phase coupling between neural activity in the 15-30 Hz beta range. During periods of sustained muscle contraction (grip), such coupling is manifest between motor cortex and the contralateral forearm muscles - measured as the cortico-muscular coherence. We examined alterations in cortico-muscular coherence in individuals with Parkinson's disease, while equating grip strength between individuals with Parkinson's disease (off their medication) and healthy control participants. We show a marked reduction in beta cortico-muscular coherence in the Parkinson's disease group, even though the grip strength was comparable between the two groups. Moreover, the reduced cortico-muscular coherence was related to motor symptoms, so that individuals with lower cortico-muscular coherence also displayed worse motor symptoms. These findings highlight the cortico-muscular coherence as a simple, effective and clinically relevant neural marker of Parkinson's disease pathology, with the potential to aid monitoring of disease progression and the efficacy of novel treatments for Parkinson's disease.

Original languageEnglish
Article numberfcab179
JournalBrain Communications
Volume3
Issue number3
DOIs
Publication statusPublished - 23 Aug 2021

Bibliographical note

Publisher Copyright:
© 2021 The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

Keywords

  • cortico-muscular coherence
  • magnetoencephalography
  • Parkinson's disease

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Cellular and Molecular Neuroscience
  • Neurology

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