Recent developments in Pickering emulsions for biomedical applications

Clarissa L.G. Harman; Mehzabin A. Patel; Stefan Guldin; Gemma Louise Davies

doi:10.1016/j.cocis.2019.01.017

Recent developments in Pickering emulsions for biomedical applications

Clarissa L.G. Harman, Mehzabin A. Patel, Stefan Guldin, Gemma Louise Davies^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Review article › peer-review

103 Citations (Scopus)

Abstract

Pickering emulsions, stabilised by organic or inorganic particles, offer long-term dispersibility of liquid droplets and resistance to coalescence. The versatility of stabilising particles and their ability to encapsulate and release cargo with high internal payload capacity makes them attractive in a wide variety of applications, ranging from catalysis to the cosmetic and food industry. While these properties make them an equally promising material platform for pharmaceutical and clinical applications, the development of Pickering emulsions for healthcare is still in its infancy. Herein, we summarise and discuss recent progress in the development of Pickering emulsions for biomedical applications, probing their design for passive diffusion-based release as well as stimuli-responsive destabilisation. We further comment on challenges and future directions of this exciting and rapidly expanding area of research.

Original language	English
Pages (from-to)	173-189
Number of pages	17
Journal	Current Opinion in Colloid and Interface Science
Volume	39
DOIs	https://doi.org/10.1016/j.cocis.2019.01.017
Publication status	Published - Feb 2019

Bibliographical note

Funding Information:
The authors acknowledge financial support from the Engineering and Physical Sciences Research Council through the Centre for Doctoral Training in Advanced Therapeutics and Nanomedicines ( EP/L01646X , supporting CLGH) and the Centre for Doctoral Training in Molecular Modelling and Materials Science ( EP/L015862/1 , supporting MAP) in support of BASF SE.

Publisher Copyright:
© 2019 Elsevier Ltd

Keywords

Biomedicine
Pickering emulsions
Stimuli-responsive
Therapeutic delivery

ASJC Scopus subject areas

Surfaces and Interfaces
Physical and Theoretical Chemistry
Polymers and Plastics
Colloid and Surface Chemistry

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10.1016/j.cocis.2019.01.017

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title = "Recent developments in Pickering emulsions for biomedical applications",

abstract = "Pickering emulsions, stabilised by organic or inorganic particles, offer long-term dispersibility of liquid droplets and resistance to coalescence. The versatility of stabilising particles and their ability to encapsulate and release cargo with high internal payload capacity makes them attractive in a wide variety of applications, ranging from catalysis to the cosmetic and food industry. While these properties make them an equally promising material platform for pharmaceutical and clinical applications, the development of Pickering emulsions for healthcare is still in its infancy. Herein, we summarise and discuss recent progress in the development of Pickering emulsions for biomedical applications, probing their design for passive diffusion-based release as well as stimuli-responsive destabilisation. We further comment on challenges and future directions of this exciting and rapidly expanding area of research.",

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author = "Harman, {Clarissa L.G.} and Patel, {Mehzabin A.} and Stefan Guldin and Davies, {Gemma Louise}",

note = "Funding Information: The authors acknowledge financial support from the Engineering and Physical Sciences Research Council through the Centre for Doctoral Training in Advanced Therapeutics and Nanomedicines ( EP/L01646X , supporting CLGH) and the Centre for Doctoral Training in Molecular Modelling and Materials Science ( EP/L015862/1 , supporting MAP) in support of BASF SE. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

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month = feb,

doi = "10.1016/j.cocis.2019.01.017",

language = "English",

volume = "39",

pages = "173--189",

journal = "Current Opinion in Colloid and Interface Science",

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AU - Harman, Clarissa L.G.

AU - Patel, Mehzabin A.

AU - Guldin, Stefan

AU - Davies, Gemma Louise

N1 - Funding Information: The authors acknowledge financial support from the Engineering and Physical Sciences Research Council through the Centre for Doctoral Training in Advanced Therapeutics and Nanomedicines ( EP/L01646X , supporting CLGH) and the Centre for Doctoral Training in Molecular Modelling and Materials Science ( EP/L015862/1 , supporting MAP) in support of BASF SE. Publisher Copyright: © 2019 Elsevier Ltd

PY - 2019/2

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N2 - Pickering emulsions, stabilised by organic or inorganic particles, offer long-term dispersibility of liquid droplets and resistance to coalescence. The versatility of stabilising particles and their ability to encapsulate and release cargo with high internal payload capacity makes them attractive in a wide variety of applications, ranging from catalysis to the cosmetic and food industry. While these properties make them an equally promising material platform for pharmaceutical and clinical applications, the development of Pickering emulsions for healthcare is still in its infancy. Herein, we summarise and discuss recent progress in the development of Pickering emulsions for biomedical applications, probing their design for passive diffusion-based release as well as stimuli-responsive destabilisation. We further comment on challenges and future directions of this exciting and rapidly expanding area of research.

AB - Pickering emulsions, stabilised by organic or inorganic particles, offer long-term dispersibility of liquid droplets and resistance to coalescence. The versatility of stabilising particles and their ability to encapsulate and release cargo with high internal payload capacity makes them attractive in a wide variety of applications, ranging from catalysis to the cosmetic and food industry. While these properties make them an equally promising material platform for pharmaceutical and clinical applications, the development of Pickering emulsions for healthcare is still in its infancy. Herein, we summarise and discuss recent progress in the development of Pickering emulsions for biomedical applications, probing their design for passive diffusion-based release as well as stimuli-responsive destabilisation. We further comment on challenges and future directions of this exciting and rapidly expanding area of research.

KW - Biomedicine

KW - Pickering emulsions

KW - Stimuli-responsive

KW - Therapeutic delivery

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U2 - 10.1016/j.cocis.2019.01.017

DO - 10.1016/j.cocis.2019.01.017

M3 - Review article

AN - SCOPUS:85062471527

SN - 1359-0294

VL - 39

SP - 173

EP - 189

JO - Current Opinion in Colloid and Interface Science

JF - Current Opinion in Colloid and Interface Science

ER -

Recent developments in Pickering emulsions for biomedical applications

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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Cite this