Recent advances in calcium-sensing receptor structures and signaling pathways

Research output: Chapter in Book/Report/Conference proceedingChapter


The calcium-sensing receptor (CaSR) is a class C GPCR that has a fundamental role in extracellular calcium homeostasis by regulating parathyroid hormone release and urinary calcium excretion. Germline mutations in the receptor cause disorders of calcium homeostasis and studies of the functional effects of these mutations has facilitated understanding of CaSR signaling and how allosteric modulators affect these responses. In the past year, five cryo-EM structures of the near full-length CaSR have been published, demonstrating how agonist-binding transmits changes in the CaSR extracellular domain to the transmembrane region to activate G proteins, and how allosteric modulators affect these structural dynamics. Additionally, several recent studies have identified CaSR interacting proteins that regulate CaSR signaling and trafficking and contribute to understanding how the receptor achieves rapid and diverse physiological responses.
Original languageEnglish
Title of host publicationG Protein-Coupled Receptors - Part B
EditorsArun K. Shukla
Number of pages15
ISBN (Print)9780323994347
Publication statusPublished - 2023

Publication series

NameProgress in Molecular Biology and Translational Science
ISSN (Print)1877-1173


Dive into the research topics of 'Recent advances in calcium-sensing receptor structures and signaling pathways'. Together they form a unique fingerprint.

Cite this