Recent advances in alkylidene carbene chemistry

Richard Grainger, Kevin Munro

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)
576 Downloads (Pure)


Alkylidene carbenes, also called alkenylidenes, are reactive intermediates in organic chemistry. Despite their high reactivity, they undergo a range of synthetically useful transformations, including highly chemo- and regioselective intramolecular 1,5 insertions into unfunctionalized C-H bonds with retention of absolute configuration. This review article covers current understanding of the structure and bonding of alkylidene carbenes, methods of generation including recent analogous chemistry displayed by metal vinylidenes, the various factors affecting chemo-, regio- and diastereoselectivity, and applications in target synthesis.
Original languageEnglish
Pages (from-to)7795–7835
Number of pages41
Issue number41
Early online date24 Jun 2015
Publication statusPublished - 14 Oct 2015


  • Alkylidene carbene
  • Alkenylidene
  • Metal vinylidene
  • C–H insertion
  • Hypervalent iodine


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