Real-Time Non-invasive Assessment of Cerebral Hemodynamics With Diffuse Optical Spectroscopies in a Neuro Intensive Care Unit: An Observational Case Study

Rodrigo M. Forti*, Marilise Katsurayama, Julien Menko, Lenise Valler, Andres Quiroga, Antonio L.E. Falcão, Li M. Li, Rickson C. Mesquita

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Prevention of secondary damage is an important goal in the treatment of severe neurological conditions, such as major head trauma or stroke. However, there is currently a lack of non-invasive methods for monitoring cerebral physiology. Diffuse optical methods have been proposed as an inexpensive, non-invasive bedside monitor capable of providing neurophysiology information in neurocritical patients. However, the reliability of the technique to provide accurate longitudinal measurement during the clinical evolution of a patient remains largely unaddressed. Here, we report on the translation of a hybrid diffuse optical system combining frequency domain diffuse optical spectroscopy (FD-DOS) and diffuse correlation spectroscopy (DCS) for real-time monitoring of cerebral physiology in a neuro intensive care unit (neuro-ICU). More specifically, we present a case study of a patient admitted with a high-grade aneurysmal subarachnoid hemorrhage, who was monitored throughout hospitalization. We show that the neurophysiological parameters measured by diffuse optics at the bedside are consistent with the clinical evolution of the patient at all the different stages following its brain lesion. These data provide support for clinical translation of DOS/DCS as a useful biomarker of neurophysiology in the neuro-ICU, particularly in locations where other clinical resources are limited.

Original languageEnglish
Article number147
JournalFrontiers in Medicine
Volume7
DOIs
Publication statusPublished - 28 Apr 2020

Bibliographical note

Funding Information:
We acknowledge the support by the São Paulo Research Foundation (FAPESP) through Proc. 2012/02500-8 (RM), 2014/25486-6 (RF) and 2013/07559-3. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Funding Information:
Funding. We acknowledge the support by the São Paulo Research Foundation (FAPESP) through Proc. 2012/02500-8 (RM), 2014/25486-6 (RF) and 2013/07559-3. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© Copyright © 2020 Forti, Katsurayama, Menko, Valler, Quiroga, Falcão, Li and Mesquita.

Keywords

  • aneurysmal subarachnoid hemorrhage
  • cerebral blood flow (CBF)
  • diffuse correlation spectroscopy (DCS)
  • diffuse optical spectroscopy (DOS)
  • neuro intensive care unit

ASJC Scopus subject areas

  • General Medicine

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