Rationale for treatment and therapeutic options in Cushing's disease

Paul Stewart, S Petersenn

Research output: Contribution to journalArticle

21 Citations (Scopus)


Cushing's disease results from prolonged overexposure of tissues to endogenous glucocorticoids, secondary to adrenocorticotrophin excess from the pituitary. Common clinical signs and symptoms include weight gain, hypertension, and osteoporosis. Effective treatment of Cushing's disease can normalize biochemical levels, reverse comorbidities, and improve overall survival and quality of life. Treatment options include pituitary or adrenal surgery, radiotherapy, and various medical therapies, but each has important limitations. Medical therapies that effectively target the pituitary tumour are urgently needed. (C) 2009 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)S15-S22
JournalBest practice & research. Clinical endocrinology & metabolism
Publication statusPublished - 1 Dec 2009


  • Cushing's syndrome
  • adrenocorticotrophic hormone (ACTH)
  • Cushing's disease
  • pituitary


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