BACKGROUND: The effect of fasting on immunity is unclear. Prolonged fasting is thought to increase the risk of infection due to dehydration. This study describes antibiotic prescribing patterns before, during, and after Ramadan in a primary care setting within the Pakistani and Bangladeshi populations in the UK, most of whom are Muslims, compared to those who do not observe Ramadan.
METHOD: Retrospective controlled interrupted time series analysis of electronic health record data from primary care practices. The study consists of two groups: Pakistanis/Bangladeshis and white populations. For each group, we constructed a series of aggregated, daily prescription data from 2007 to 2017 for the 30 days preceding, during, and after Ramadan, respectively.
FINDINGS: Controlling for the rate in the white population, there was no evidence of increased antibiotic prescription in the Pakistani/Bangladeshi population during Ramadan, as compared to before Ramadan (IRR: 0.994; 95% CI: 0.988-1.001, p = 0.082) or after Ramadan (IRR: 1.006; 95% CI: 0.999-1.013, p = 0.082).
INTERPRETATION: In this large, population-based study, we did not find any evidence to suggest that fasting was associated with an increased susceptibility to infection.
Bibliographical noteFunding Information:
Our thanks to Tom Taverner for discussions on statistical analysis.
Copyright: © 2022 Almulhem et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Anti-Bacterial Agents/therapeutic use
- Communicable Disease Control/methods
- Communicable Diseases/drug therapy
- Disease Susceptibility/metabolism
- Electronic Health Records
- Fasting/adverse effects
- Interrupted Time Series Analysis/methods
- Middle Aged
- Practice Patterns, Physicians'
- Primary Health Care/trends
- Retrospective Studies
- United Kingdom/epidemiology