TY - JOUR
T1 - Radiation doses received by major organs at risk in children and young adolescents treated for cancer with external beam radiation therapy
T2 - a large-scale study from 12 European countries
AU - Diallo, Ibrahima
AU - Allodji, Rodrigue S.
AU - Veres, Cristina
AU - Bolle, Stéphanie
AU - Llanas, Damien
AU - Ezzouhri, Safaa
AU - Zrafi, Wael
AU - Debiche, Ghazi
AU - Souchard, Vincent
AU - Fauchery, Romain
AU - Haddy, Nadia
AU - Journy, Neige
AU - Demoor-Goldschmidt, Charlotte
AU - Winter, David L.
AU - Hjorth, Lars
AU - Wiebe, Thomas
AU - Haupt, Riccardo
AU - Robert, Charlotte
AU - Kremer, Leontien
AU - Bardi, Edit
AU - Sacerdote, Carlotta
AU - Terenziani, Monica
AU - Kuehni, Claudia E.
AU - Schindera, Christina
AU - Skinner, Roderick
AU - Winther, Jeanette Falck
AU - Lähteenmäki, Päivi
AU - Byrn, Julianne
AU - Jakab, Zsuzsanna
AU - Cardis, Elisabeth
AU - Pasqual, Elisa
AU - Tapio, Soile
AU - Baatout, Sarah
AU - Atkinson, Mike
AU - Benotmane, Mohammed Abderrafi
AU - Sugden, Elaine
AU - Zaletel, Lorna Zadravec
AU - Ronckers, Cecile
AU - Reulen, Raoul C.
AU - Hawkins, Mike M.
AU - de Vathaire, Florent
N1 - Funding:
The PanCareSurFup consortium and related work was supported by the European Union's Seventh Framework Programme for research, technological development and demonstration under grant agreement no. 257505. The ProCardio consortium was supported by the European Community's Seventh Framework Programme EURATOM under grant agreement no. 295823. The CEREBRAD consortium was supported by the European Community's Seventh Framework Programme EURATOM under grant agreement no. 295552.
PY - 2024/4/4
Y1 - 2024/4/4
N2 - Background:Childhood cancer survivors are at high risk of long-term iatrogenic events, in particular those treated with radiotherapy. The prediction of risk of such events is mainly based on the knowledge of the radiation dose received to healthy organs and tissues during treatment of childhood cancer diagnosed decades ago. Purpose: We aimed to set up a standardised organ dose table in order to help former patients and clinician in charge of long term follow-up clinics. Material and methods: We performed whole body dosimetric reconstruction for 2646 patients from 12 European Countries treated between 1941 and 2006 (median: 1976). Most planning were 2D or 3D, 46% of patients were treated using Cobalt 60 and 41% using linear accelerator, the median prescribed dose being 27.2 Gy (IQ1-IQ3: 17.6-40.0 Gy), A patient specific voxel-based anthropomorphic phantom with more than 200 anatomical structures or sub-structures delineated as a surrogate of each subject's anatomy was used. The radiation therapy was simulated with a treatment planning system (TPS) based on available treatment information. The radiation dose received by any organ of the body was estimated by extending the TPS dose calculation to the whole-body, by type and localisation of childhood cancer. Results: The integral dose and normal-tissue doses to most of the 23 considered organs increased between the 1950’s and the 1970’s and decreased or plateaued thereafter. Whatever the organ considered, the type of childhood cancer explained most of the variability in organ dose. The country of treatment explained only a small part of the variability. Conclusion: The detailed dose estimates provide very useful information for former patients or clinicians who have only limited knowledge about radiation therapy protocols or techniques, but who know the type and site of childhood cancer, gender, age and year of treatment. This will allow better prediction of the long-term risk of iatrogenic events and better referral to long-term follow-up clinics.
AB - Background:Childhood cancer survivors are at high risk of long-term iatrogenic events, in particular those treated with radiotherapy. The prediction of risk of such events is mainly based on the knowledge of the radiation dose received to healthy organs and tissues during treatment of childhood cancer diagnosed decades ago. Purpose: We aimed to set up a standardised organ dose table in order to help former patients and clinician in charge of long term follow-up clinics. Material and methods: We performed whole body dosimetric reconstruction for 2646 patients from 12 European Countries treated between 1941 and 2006 (median: 1976). Most planning were 2D or 3D, 46% of patients were treated using Cobalt 60 and 41% using linear accelerator, the median prescribed dose being 27.2 Gy (IQ1-IQ3: 17.6-40.0 Gy), A patient specific voxel-based anthropomorphic phantom with more than 200 anatomical structures or sub-structures delineated as a surrogate of each subject's anatomy was used. The radiation therapy was simulated with a treatment planning system (TPS) based on available treatment information. The radiation dose received by any organ of the body was estimated by extending the TPS dose calculation to the whole-body, by type and localisation of childhood cancer. Results: The integral dose and normal-tissue doses to most of the 23 considered organs increased between the 1950’s and the 1970’s and decreased or plateaued thereafter. Whatever the organ considered, the type of childhood cancer explained most of the variability in organ dose. The country of treatment explained only a small part of the variability. Conclusion: The detailed dose estimates provide very useful information for former patients or clinicians who have only limited knowledge about radiation therapy protocols or techniques, but who know the type and site of childhood cancer, gender, age and year of treatment. This will allow better prediction of the long-term risk of iatrogenic events and better referral to long-term follow-up clinics.
U2 - 10.1016/j.ijrobp.2024.03.032
DO - 10.1016/j.ijrobp.2024.03.032
M3 - Article
SN - 0360-3016
JO - International Journal of Radiation: Oncology - Biology - Physics
JF - International Journal of Radiation: Oncology - Biology - Physics
ER -