Protein-tyrosine phosphatases and cancer

Arne Ostman, Carina Hellberg, Frank D Böhmer, Karina Hellberg

Research output: Contribution to journalArticlepeer-review

486 Citations (Scopus)


Tyrosine phosphorylation is an important signalling mechanism in eukaryotic cells. In cancer, oncogenic activation of tyrosine kinases is a common feature, and novel anticancer drugs have been introduced that target these enzymes. Tyrosine phosphorylation is also controlled by protein-tyrosine phosphatases (PTPs). Recent evidence has shown that PTPs can function as tumour suppressors. In addition, some PTPs, including SHP2, positively regulate the signalling of growth-factor receptors, and can be oncogenic. An improved understanding of how these enzymes function and how they are regulated might aid the development of new anticancer agents.
Original languageEnglish
Pages (from-to)307-20
Number of pages14
JournalNature Reviews Cancer
Issue number4
Publication statusPublished - 2006


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