Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants

Gideon M Hirschfield, Xiangdong Liu, Chun Xu, Yue Lu, Gang Xie, Yan Lu, Xiangjun Gu, Erin J Walker, Kaiyan Jing, Brian D Juran, Andrew L Mason, Robert P Myers, Kevork M Peltekian, Cameron N Ghent, Catalina Coltescu, Elizabeth J Atkinson, E Jenny Heathcote, Konstantinos N Lazaridis, Christopher I Amos, Katherine A Siminovitch

Research output: Contribution to journalArticlepeer-review

467 Citations (Scopus)


Primary biliary cirrhosis is a chronic granulomatous cholangitis, characteristically associated with antimitochondrial antibodies. Twin and family aggregation data suggest that there is a significant genetic predisposition to primary biliary cirrhosis, but the susceptibility loci are unknown.
Original languageEnglish
Pages (from-to)2544-55
Number of pages12
JournalNew England Journal of Medicine
Issue number24
Publication statusPublished - 2009


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