Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants

Gideon M Hirschfield; Xiangdong Liu; Chun Xu; Yue Lu; Gang Xie; Yan Lu; Xiangjun Gu; Erin J Walker; Kaiyan Jing; Brian D Juran; Andrew L Mason; Robert P Myers; Kevork M Peltekian; Cameron N Ghent; Catalina Coltescu; Elizabeth J Atkinson; E Jenny Heathcote; Konstantinos N Lazaridis; Christopher I Amos; Katherine A Siminovitch

doi:10.1056/NEJMoa0810440

Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants

Gideon M Hirschfield, Xiangdong Liu, Chun Xu, Yue Lu, Gang Xie, Yan Lu, Xiangjun Gu, Erin J Walker, Kaiyan Jing, Brian D Juran, Andrew L Mason, Robert P Myers, Kevork M Peltekian, Cameron N Ghent, Catalina Coltescu, Elizabeth J Atkinson, E Jenny Heathcote, Konstantinos N Lazaridis, Christopher I Amos, Katherine A Siminovitch

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

467 Citations (Scopus)

Abstract

Primary biliary cirrhosis is a chronic granulomatous cholangitis, characteristically associated with antimitochondrial antibodies. Twin and family aggregation data suggest that there is a significant genetic predisposition to primary biliary cirrhosis, but the susceptibility loci are unknown.

Original language	English
Pages (from-to)	2544-55
Number of pages	12
Journal	New England Journal of Medicine
Volume	360
Issue number	24
DOIs	https://doi.org/10.1056/NEJMoa0810440
Publication status	Published - 2009

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Hirschfield, G. M., Liu, X., Xu, C., Lu, Y., Xie, G., Lu, Y., Gu, X., Walker, E. J., Jing, K., Juran, B. D., Mason, A. L., Myers, R. P., Peltekian, K. M., Ghent, C. N., Coltescu, C., Atkinson, E. J., Heathcote, E. J., Lazaridis, K. N., Amos, C. I., & Siminovitch, K. A. (2009). Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. New England Journal of Medicine, 360(24), 2544-55. https://doi.org/10.1056/NEJMoa0810440

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title = "Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants",

abstract = "Primary biliary cirrhosis is a chronic granulomatous cholangitis, characteristically associated with antimitochondrial antibodies. Twin and family aggregation data suggest that there is a significant genetic predisposition to primary biliary cirrhosis, but the susceptibility loci are unknown.",

author = "Hirschfield, {Gideon M} and Xiangdong Liu and Chun Xu and Yue Lu and Gang Xie and Yan Lu and Xiangjun Gu and Walker, {Erin J} and Kaiyan Jing and Juran, {Brian D} and Mason, {Andrew L} and Myers, {Robert P} and Peltekian, {Kevork M} and Ghent, {Cameron N} and Catalina Coltescu and Atkinson, {Elizabeth J} and Heathcote, {E Jenny} and Lazaridis, {Konstantinos N} and Amos, {Christopher I} and Siminovitch, {Katherine A}",

note = "2009 Massachusetts Medical Society",

year = "2009",

doi = "10.1056/NEJMoa0810440",

language = "English",

volume = "360",

pages = "2544--55",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachusetts Medical Society",

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Hirschfield, GM, Liu, X, Xu, C, Lu, Y, Xie, G, Lu, Y, Gu, X, Walker, EJ, Jing, K, Juran, BD, Mason, AL, Myers, RP, Peltekian, KM, Ghent, CN, Coltescu, C, Atkinson, EJ, Heathcote, EJ, Lazaridis, KN, Amos, CI & Siminovitch, KA 2009, 'Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants', New England Journal of Medicine, vol. 360, no. 24, pp. 2544-55. https://doi.org/10.1056/NEJMoa0810440

TY - JOUR

T1 - Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants

AU - Hirschfield, Gideon M

AU - Liu, Xiangdong

AU - Xu, Chun

AU - Lu, Yue

AU - Xie, Gang

AU - Lu, Yan

AU - Gu, Xiangjun

AU - Walker, Erin J

AU - Jing, Kaiyan

AU - Juran, Brian D

AU - Mason, Andrew L

AU - Myers, Robert P

AU - Peltekian, Kevork M

AU - Ghent, Cameron N

AU - Coltescu, Catalina

AU - Atkinson, Elizabeth J

AU - Heathcote, E Jenny

AU - Lazaridis, Konstantinos N

AU - Amos, Christopher I

AU - Siminovitch, Katherine A

N1 - 2009 Massachusetts Medical Society

PY - 2009

Y1 - 2009

N2 - Primary biliary cirrhosis is a chronic granulomatous cholangitis, characteristically associated with antimitochondrial antibodies. Twin and family aggregation data suggest that there is a significant genetic predisposition to primary biliary cirrhosis, but the susceptibility loci are unknown.

AB - Primary biliary cirrhosis is a chronic granulomatous cholangitis, characteristically associated with antimitochondrial antibodies. Twin and family aggregation data suggest that there is a significant genetic predisposition to primary biliary cirrhosis, but the susceptibility loci are unknown.

U2 - 10.1056/NEJMoa0810440

DO - 10.1056/NEJMoa0810440

M3 - Article

C2 - 19458352

SN - 0028-4793

VL - 360

SP - 2544

EP - 2555

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 24

ER -

Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants

Abstract

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