Preparation and size optimisation of silica nanoparticles using statistical analyses

Gemma Louise Davies; Antoinette Barry; Yurii K. Gun'ko

doi:10.1016/j.cplett.2008.12.031

Preparation and size optimisation of silica nanoparticles using statistical analyses

Gemma Louise Davies, Antoinette Barry, Yurii K. Gun'ko^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Silica nanoparticles with narrow size distribution have been prepared by hydrolysis of tetraethylorthosilicate in ethanol and the presence of ammonia. Variation of reagent concentrations using statistical analyses (factorial design) was used for the first time to optimise the preparation of small sized silica nanoparticles with small standard deviation. Statistical analyses showed there is no significant correlation between reagent concentrations, which have an impact on the resultant particle size. Various agitation methods employed in silica nanoparticle preparation were investigated. Utilisation of an ultrasonic tip has led to dramatic reduction in reaction times, while still providing silica particles of small uniform sizes.

Original language	English
Pages (from-to)	239-244
Number of pages	6
Journal	Chemical Physics Letters
Volume	468
Issue number	4-6
DOIs	https://doi.org/10.1016/j.cplett.2008.12.031
Publication status	Published - 22 Jan 2009

Bibliographical note

Funding Information:
The authors would like to thank Science Foundation Ireland (SFI), Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) and Trinity College Dublin (TCD) for funding as well as the Centre for Microscopy and Analysis (CMA), TCD for assistance with TEM imaging.

ASJC Scopus subject areas

General Physics and Astronomy
Physical and Theoretical Chemistry

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10.1016/j.cplett.2008.12.031

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abstract = "Silica nanoparticles with narrow size distribution have been prepared by hydrolysis of tetraethylorthosilicate in ethanol and the presence of ammonia. Variation of reagent concentrations using statistical analyses (factorial design) was used for the first time to optimise the preparation of small sized silica nanoparticles with small standard deviation. Statistical analyses showed there is no significant correlation between reagent concentrations, which have an impact on the resultant particle size. Various agitation methods employed in silica nanoparticle preparation were investigated. Utilisation of an ultrasonic tip has led to dramatic reduction in reaction times, while still providing silica particles of small uniform sizes.",

author = "Davies, {Gemma Louise} and Antoinette Barry and Gun'ko, {Yurii K.}",

note = "Funding Information: The authors would like to thank Science Foundation Ireland (SFI), Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) and Trinity College Dublin (TCD) for funding as well as the Centre for Microscopy and Analysis (CMA), TCD for assistance with TEM imaging.",

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AU - Davies, Gemma Louise

AU - Barry, Antoinette

AU - Gun'ko, Yurii K.

N1 - Funding Information: The authors would like to thank Science Foundation Ireland (SFI), Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) and Trinity College Dublin (TCD) for funding as well as the Centre for Microscopy and Analysis (CMA), TCD for assistance with TEM imaging.

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AB - Silica nanoparticles with narrow size distribution have been prepared by hydrolysis of tetraethylorthosilicate in ethanol and the presence of ammonia. Variation of reagent concentrations using statistical analyses (factorial design) was used for the first time to optimise the preparation of small sized silica nanoparticles with small standard deviation. Statistical analyses showed there is no significant correlation between reagent concentrations, which have an impact on the resultant particle size. Various agitation methods employed in silica nanoparticle preparation were investigated. Utilisation of an ultrasonic tip has led to dramatic reduction in reaction times, while still providing silica particles of small uniform sizes.

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JO - Chemical Physics Letters

JF - Chemical Physics Letters

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Preparation and size optimisation of silica nanoparticles using statistical analyses

Abstract

Bibliographical note

ASJC Scopus subject areas

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