Potential Antitumor Effect of α-Mangostin against Rat Mammary Gland Tumors Induced by LA7 Cells

Mohamed Yousif Ibrahim*, Najihah Mohd Hashim, Fatima Abdelmutaal Ahmed Omer, Muhammad Salisu Abubakar, Hoyam Adam Mohammed, Suzy Munir Salama, Soher Nagi Jayash*, Adam Jarmuła (Editor), Piotr Maj (Editor)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

In this study, the chemotherapeutic effect of α-mangostin (AM) was assessed in rats injected with LA7 cells. Rats received AM orally at 30 and 60 mg/kg twice a week for 4 weeks. Cancer biomarkers such as CEA and CA 15-3 were significantly lower in AM-treated rats. Histopathological evaluations showed that AM protects the rat mammary gland from the carcinogenic effects of LA7 cells. Interestingly, AM decreased lipid peroxidation and increased antioxidant enzymes when compared to the control. Immunohistochemistry results of the untreated rats showed abundant PCNA and fewer p53-positive cells than AM-treated rats. Using the TUNEL test, AM-treated animals had higher apoptotic cell numbers than those untreated. This report revealed that that AM lessened oxidative stress, suppressed proliferation, and minimized LA7-induced mammary carcinogenesis. Therefore, the current study suggests that AM has significant potential for breast cancer treatment.
Original languageEnglish
Article number10283
JournalInternational Journal of Molecular Sciences
Volume24
Issue number12
DOIs
Publication statusPublished - 17 Jun 2023

Keywords

  • mammary cancer
  • LA7 cells
  • immunohistochemistry
  • α-mangostin
  • antioxidant
  • apoptosis

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