Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38

Andrew R. Clark*, Jonathan L.E. Dean, Jeremy Saklatvala

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

168 Citations (Scopus)


The mitogen-activated protein kinase p38 pathway was originally identified as a signalling cascade activated by pro-inflammatory stimuli and cellular stresses, and playing a critical role in the translational regulation of pro-inflammatory cytokine synthesis. In almost a decade since this discovery, a great deal has been learned about the role of the p38 pathway in the post-transcriptional regulation of pro-inflammatory gene expression. However, important questions remain to be answered concerning the specificity and mechanism or mechanisms of action of p38. This review describes recent progress and remaining puzzles in the field of post-transcriptional regulation by p38.

Original languageEnglish
Pages (from-to)37-44
Number of pages8
JournalFEBS Letters
Issue number1
Publication statusPublished - 3 Jul 2003


  • Adenosine/uridine rich element
  • Inflammation
  • MAPK p38
  • mRNA stability
  • Translation

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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