Abstract
We have investigated the possibility that the costimulatory signals required for activation of mature T cells also play a role in providing differentiation signals for positive selection during T-cell development. We show that purified MHC Class II+thymic epithelial cells are able to support positive selection in vitro but lack both the functional capacity to deliver costimulatory signals and expression of the costimulatory ligand B7. Our results suggest that the additional signals provided by costimulatory ligands are not required for TCR-mediated positive selection, although other ancillary signals provided by thymic epithelial cells may be involved.
Original language | English |
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Pages (from-to) | 265-271 |
Number of pages | 7 |
Journal | Developmental Immunology |
Volume | 3 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1994 |
Keywords
- costimulation
- fetal thymus
- organ culture
- Positive selection
- thymic epithelium
ASJC Scopus subject areas
- Immunology
- Developmental Biology