Positive Selection By Purified Mhc Class II+ Thymic Epithelial Cells in Vitro: Costimulatory Signals Mediated By B7 are Not Involved

Eric J. Jenkinson*, Graham Anderson, Nel C. Moore, Christopher A. Smith, John J.T. Owen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

We have investigated the possibility that the costimulatory signals required for activation of mature T cells also play a role in providing differentiation signals for positive selection during T-cell development. We show that purified MHC Class II+thymic epithelial cells are able to support positive selection in vitro but lack both the functional capacity to deliver costimulatory signals and expression of the costimulatory ligand B7. Our results suggest that the additional signals provided by costimulatory ligands are not required for TCR-mediated positive selection, although other ancillary signals provided by thymic epithelial cells may be involved.

Original languageEnglish
Pages (from-to)265-271
Number of pages7
JournalDevelopmental Immunology
Volume3
Issue number4
DOIs
Publication statusPublished - 1994

Keywords

  • costimulation
  • fetal thymus
  • organ culture
  • Positive selection
  • thymic epithelium

ASJC Scopus subject areas

  • Immunology
  • Developmental Biology

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