Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils

R Cockeran; H C Steel; T J Mitchell; C Feldman; R Anderson

doi:10.1128/IAI.69.5.3494-3496.2001

Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils

R Cockeran, H C Steel, T J Mitchell, C Feldman, R Anderson

Microbiology and Infection

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Exposure to pneumolysin (8.37 and 41.75 ng/ml) caused a calcium-dependent increase in the generation of prostaglandin E(2) and leukotriene B(4) by both resting and chemoattractant-activated human neutrophils in vitro. These interactions of pneumolysin with neutrophils may result in dysregulation of inflammatory responses during pneumococcal infection.

Original language	English
Pages (from-to)	3494-6
Number of pages	3
Journal	Infection and Immunity
Volume	69
Issue number	5
DOIs	https://doi.org/10.1128/IAI.69.5.3494-3496.2001
Publication status	Published - May 2001

Keywords

Adult
Bacterial Proteins
Dinoprostone
Humans
Leukotriene B4
N-Formylmethionine Leucyl-Phenylalanine
Neutrophils
Pneumococcal Infections
Streptolysins

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10.1128/IAI.69.5.3494-3496.2001

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title = "Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils",

abstract = "Exposure to pneumolysin (8.37 and 41.75 ng/ml) caused a calcium-dependent increase in the generation of prostaglandin E(2) and leukotriene B(4) by both resting and chemoattractant-activated human neutrophils in vitro. These interactions of pneumolysin with neutrophils may result in dysregulation of inflammatory responses during pneumococcal infection.",

keywords = "Adult, Bacterial Proteins, Dinoprostone, Humans, Leukotriene B4, N-Formylmethionine Leucyl-Phenylalanine, Neutrophils, Pneumococcal Infections, Streptolysins",

author = "R Cockeran and Steel, {H C} and Mitchell, {T J} and C Feldman and R Anderson",

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doi = "10.1128/IAI.69.5.3494-3496.2001",

language = "English",

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publisher = "American Society for Microbiology",

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TY - JOUR

T1 - Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils

AU - Cockeran, R

AU - Steel, H C

AU - Mitchell, T J

AU - Feldman, C

AU - Anderson, R

PY - 2001/5

Y1 - 2001/5

N2 - Exposure to pneumolysin (8.37 and 41.75 ng/ml) caused a calcium-dependent increase in the generation of prostaglandin E(2) and leukotriene B(4) by both resting and chemoattractant-activated human neutrophils in vitro. These interactions of pneumolysin with neutrophils may result in dysregulation of inflammatory responses during pneumococcal infection.

AB - Exposure to pneumolysin (8.37 and 41.75 ng/ml) caused a calcium-dependent increase in the generation of prostaglandin E(2) and leukotriene B(4) by both resting and chemoattractant-activated human neutrophils in vitro. These interactions of pneumolysin with neutrophils may result in dysregulation of inflammatory responses during pneumococcal infection.

KW - Adult

KW - Bacterial Proteins

KW - Dinoprostone

KW - Humans

KW - Leukotriene B4

KW - N-Formylmethionine Leucyl-Phenylalanine

KW - Neutrophils

KW - Pneumococcal Infections

KW - Streptolysins

U2 - 10.1128/IAI.69.5.3494-3496.2001

DO - 10.1128/IAI.69.5.3494-3496.2001

M3 - Article

C2 - 11292782

SN - 0019-9567

VL - 69

SP - 3494

EP - 3496

JO - Infection and Immunity

JF - Infection and Immunity

IS - 5

ER -

Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils

Abstract

Keywords

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