Plasma levels of matrix metalloproteinases and their inhibitors in hypertension:  a systematic review and meta-analysis.

C Marchesi; F Dentali; E Nicolini; AM Maresca; MH Tayebjee; M Franz; L Guasti; A Venco; EL Schiffrin; Gregory Lip; AM Grandi

doi:10.1097/HJH.0b013e32834d249a

Plasma levels of matrix metalloproteinases and their inhibitors in hypertension: a systematic review and meta-analysis.

C Marchesi, F Dentali, E Nicolini, AM Maresca, MH Tayebjee, M Franz, L Guasti, A Venco, EL Schiffrin, Gregory Lip, AM Grandi

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Abstract

BACKGROUND: Hypertension is a major cause of cardiovascular remodeling. In the cardiovascular system, the remodeling of the extracellular matrix is controlled by the matrix metalloproteinases (MMPs) and the tissue inhibitors of MMPs (TIMPs). The aim of this meta-analysis is to elucidate the behavior of plasma MMP and TIMP levels in hypertension and their relationship to cardiovascular remodeling. METHODS: MEDLINE and EMBASE databases were searched up to July 2011. Studies were considered eligible if they provided values of plasma MMPs and TIMPs in hypertensive patients. Given the high variability of the plasma biomarker values among studies, the standardized mean difference (SMD) was calculated. RESULTS: Ten studies provided plasma MMP-9; the SMD between 778 hypertensive patients and 669 controls was 1.95 units (P

Original language	English
Journal	Journal of Hypertension
DOIs	https://doi.org/10.1097/HJH.0b013e32834d249a
Publication status	Published - 30 Nov 2011

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title = "Plasma levels of matrix metalloproteinases and their inhibitors in hypertension: a systematic review and meta-analysis.",

abstract = "BACKGROUND: Hypertension is a major cause of cardiovascular remodeling. In the cardiovascular system, the remodeling of the extracellular matrix is controlled by the matrix metalloproteinases (MMPs) and the tissue inhibitors of MMPs (TIMPs). The aim of this meta-analysis is to elucidate the behavior of plasma MMP and TIMP levels in hypertension and their relationship to cardiovascular remodeling. METHODS: MEDLINE and EMBASE databases were searched up to July 2011. Studies were considered eligible if they provided values of plasma MMPs and TIMPs in hypertensive patients. Given the high variability of the plasma biomarker values among studies, the standardized mean difference (SMD) was calculated. RESULTS: Ten studies provided plasma MMP-9; the SMD between 778 hypertensive patients and 669 controls was 1.95 units (P ",

author = "C Marchesi and F Dentali and E Nicolini and AM Maresca and MH Tayebjee and M Franz and L Guasti and A Venco and EL Schiffrin and Gregory Lip and AM Grandi",

year = "2011",

month = nov,

day = "30",

doi = "10.1097/HJH.0b013e32834d249a",

language = "English",

journal = "Journal of Hypertension",

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TY - JOUR

T1 - Plasma levels of matrix metalloproteinases and their inhibitors in hypertension: a systematic review and meta-analysis.

AU - Marchesi, C

AU - Dentali, F

AU - Nicolini, E

AU - Maresca, AM

AU - Tayebjee, MH

AU - Franz, M

AU - Guasti, L

AU - Venco, A

AU - Schiffrin, EL

AU - Lip, Gregory

AU - Grandi, AM

PY - 2011/11/30

Y1 - 2011/11/30

N2 - BACKGROUND: Hypertension is a major cause of cardiovascular remodeling. In the cardiovascular system, the remodeling of the extracellular matrix is controlled by the matrix metalloproteinases (MMPs) and the tissue inhibitors of MMPs (TIMPs). The aim of this meta-analysis is to elucidate the behavior of plasma MMP and TIMP levels in hypertension and their relationship to cardiovascular remodeling. METHODS: MEDLINE and EMBASE databases were searched up to July 2011. Studies were considered eligible if they provided values of plasma MMPs and TIMPs in hypertensive patients. Given the high variability of the plasma biomarker values among studies, the standardized mean difference (SMD) was calculated. RESULTS: Ten studies provided plasma MMP-9; the SMD between 778 hypertensive patients and 669 controls was 1.95 units (P

AB - BACKGROUND: Hypertension is a major cause of cardiovascular remodeling. In the cardiovascular system, the remodeling of the extracellular matrix is controlled by the matrix metalloproteinases (MMPs) and the tissue inhibitors of MMPs (TIMPs). The aim of this meta-analysis is to elucidate the behavior of plasma MMP and TIMP levels in hypertension and their relationship to cardiovascular remodeling. METHODS: MEDLINE and EMBASE databases were searched up to July 2011. Studies were considered eligible if they provided values of plasma MMPs and TIMPs in hypertensive patients. Given the high variability of the plasma biomarker values among studies, the standardized mean difference (SMD) was calculated. RESULTS: Ten studies provided plasma MMP-9; the SMD between 778 hypertensive patients and 669 controls was 1.95 units (P

U2 - 10.1097/HJH.0b013e32834d249a

DO - 10.1097/HJH.0b013e32834d249a

M3 - Article

C2 - 22134384

SN - 1473-5598

JO - Journal of Hypertension

JF - Journal of Hypertension

ER -

Plasma levels of matrix metalloproteinases and their inhibitors in hypertension: a systematic review and meta-analysis.

Abstract

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